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Selenium analogs of raloxifene: antioxidant activity endowed to an old drug

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Chemistry of Heterocyclic Compounds Aims and scope

The antioxidant activity of selenium-containing analogs of raloxifene was studied by the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and peroxyl radicals. These compounds exhibited similar scavenging properties as resveratrol with respect to superoxide radical and had an impressive activity in peroxyl radical scavenging, making them promising candidates for the development of antioxidant agents.

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The financial support of this work provided by the Latvian Council of Science (grant No. 447/2012) is gratefully acknowledged.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St, Riga, LV-1006, Latvia

    Ilona Domracheva, Anita Gulbe, Edgars Paegle & Pavel Arsenyan

Authors
  1. Ilona Domracheva
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  2. Anita Gulbe
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  3. Edgars Paegle
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  4. Pavel Arsenyan
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Corresponding author

Correspondence to Pavel Arsenyan.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2016, 52(8), 551–554

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Domracheva, I., Gulbe, A., Paegle, E. et al. Selenium analogs of raloxifene: antioxidant activity endowed to an old drug. Chem Heterocycl Comp 52, 551–554 (2016). https://doi.org/10.1007/s10593-016-1929-0

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  • DOI: https://doi.org/10.1007/s10593-016-1929-0

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