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Synthesis of 3-aryl-5-diethoxyphosphorylethyne-4,5-dihydroisoxazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A convenient preparative method has been developed for obtaining a vinylacetylene phosphonate. The reaction of arylnitrile oxides with 4-(diethylphosphoryl)-2-methylbut-1-en-3-yne proceeds as a regioselective 1,3-dipolar cycloaddition exclusively at the terminal double bond of vinylacetylene phosphonate.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi Ave, Chernogolovka, 142432, Russia

    V. K. Brel’

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  1. V. K. Brel’
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Correspondence to V. K. Brel’.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 977-981, June, 2012.

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Brel’, V.K. Synthesis of 3-aryl-5-diethoxyphosphorylethyne-4,5-dihydroisoxazoles. Chem Heterocycl Comp 48, 907–911 (2012). https://doi.org/10.1007/s10593-012-1075-2

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  • DOI: https://doi.org/10.1007/s10593-012-1075-2

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