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Synthesis and cytotoxicity of metal 4-methyl-8-quinolinethiolates

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

It has been shown that the introduction of a methyl group at position 4 of the quinoline ring in metal 8-quinolinethiolates brings about a significant increase in the selectivity of their cytotoxic activity. It was found that rhodium 4-methyl-8-quinolinethiolate is 46 times less toxic than the unsubstituted 8-quinolinethiolate but with comparable toxicity towards MG-22A tumor cells (LC50 2 µg/ml).

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, LV-1006

    E. Lukevics, I. Shestakova, I. Domracheva & E. Yashchenko

  2. RTU Institute of Inorganic Chemistry, Salaspils, LV-2169

    D. Zaruma & J. Ashaks

Authors
  1. E. Lukevics
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  2. I. Shestakova
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  3. I. Domracheva
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  4. E. Yashchenko
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  5. D. Zaruma
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  6. J. Ashaks
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 755–758, May, 2007.

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Lukevics, E., Shestakova, I., Domracheva, I. et al. Synthesis and cytotoxicity of metal 4-methyl-8-quinolinethiolates. Chem Heterocycl Compd 43, 634–636 (2007). https://doi.org/10.1007/s10593-007-0098-6

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  • DOI: https://doi.org/10.1007/s10593-007-0098-6

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