Abstract
During September 16th–20th 2016, metastasis experts from around the world convened for the 16th Biennial Congress of the Metastasis Research Society and 12th National Congress of the Chinese Tumor Metastasis Society in Chengdu, China to share most current data covering basic, translational, and clinical metastasis research. Presentations of the more than 40 invited speakers of the main congress and presentations from the associated Young Investigator Satellite Meeting are summarized in this report by session topic. The congress program also included three concurrent short talk sessions, an advocacy forum with Chinese and American metastatic patient advocates, a ‘Meet the Professors Roundtable’ session for young investigators, and a ‘Meet the Editors’ session with editors from Cancer Cell and Nature Cell Biology. The goal of integrating expertise and exchanging the latest findings, ideas, and practices in cancer metastasis research was achieved magnificently, thanks to the excellent contributions of many leaders in the field.
Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.References
World Health Organization (2016) Fact sheet on cancer. World Health Organization. http://www.who.int/cancer/en/. Accessed 02 Nov 2016
Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y et al (2016) Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 165:45–60
Valiente M, Obenauf AC, Jin X, Chen Q, X.H.-F. Zhang, Lee DJ et al (2014) Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell 156:1002–1016
Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A et al (2016) Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533:493–498
Nieto MA, R.Y.-J. Huang, Jackson RA, Thiery JP, EMT: 2016. Cell 166(1):21–45
Ferrer-Vaquer A, Viotti M, Hadjantonakis A-K (2010) Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo. Cell Adhes Migr 4:447–457
Meacham CE, Morrison SJ (2013) Tumour heterogeneity and cancer cell plasticity. Nature 501:328–337
Marjanovic ND, Weinberg RA, Chaffer CL (2013) Cell plasticity and heterogeneity in cancer. Clin Chem 59:168–179
Akalay I, Janji B, Hasmim M, Noman MZ, Thiery JP, Mami-Chouaib F et al (2013) EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction. Autophagy 9:1104–1106
Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE et al (2015) Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol 17:678–688
Yu Y, Wu J, Wang Y, Zhao T, Ma B, Liu Y et al (2012) Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling. EMBO Rep 13:750–758
Nobusue H, Onishi N, Shimizu T, Sugihara E, Oki Y, Sumikawa Y et al (2014) Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat Commun 5:3368
Yao C, Su L, Shan J, Zhu C, Liu L, Liu C et al (2016) IGF/STAT3/NANOG/Slug signaling axis simultaneously controls epithelial-mesenchymal transition and stemness maintenance in colorectal cancer. Stem Cells 34:820–831
Wang H, Yu C, Gao X, Welte T, Muscarella AM, Tian L et al (2015) The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell 27:193–210
Ye Q-H, Zhu W-W, Zhang J-B, Qin Y, Lu M, Lin G-L et al (2016) GOLM1 Modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis. Cancer Cell 30:444–458
Tabariès S, Siegel PM (2016) The role of claudins in cancer metastasis. Oncogene. doi:10.1038/onc.2016.289
Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S et al (2015) Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nat Med 21:1262–1271
Mohme M, Riethdorf S, Pantel K (2016) Circulating and disseminated tumour cells: mechanisms of immune surveillance and escape. Nat Rev Clin Oncol. doi:10.1038/nrclinonc.2016.144
Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H et al (2013) The perivascular niche regulates breast tumour dormancy. Nat Cell Biol 15:807–817
L. Zhang, L.D. Ridgway, M.D. Wetzel, J. Ngo, W. Yin, D. Kumar et al, The identification and characterization of breast cancer CTCs competent for brain metastasis. Sci Transl Med 5 (2013) 180ra48
Vishnoi M, Peddibhotla S, Yin W, Scamardo AT, George GC, Hong DS et al (2015) The isolation and characterization of CTC subsets related to breast cancer dormancy. Sci Rep 5:17533
Alix-Panabières C, Pantel K (2016) Clinical applications of circulating tumor cells and circulating tumor dna as liquid biopsy. Cancer Discov 6:479–491
Hvichia GE, Parveen Z, Wagner C, Janning M, Quidde J, Stein A et al (2016) A novel microfluidic platform for size and deformability based separation and the subsequent molecular characterization of viable circulating tumor cells. Int J Cancer 138:2894–2904
Gorges TM, Penkalla N, Schalk T, Joosse SA, Riethdorf S, Tucholski J et al (2016) Enumeration and molecular characterization of tumor cells in lung cancer patients using a novel in vivo device for capturing circulating tumor cells. Clin Cancer Res 22:2197–2206
Janni WJ, Rack B, L.W.M.M. Terstappen, Pierga J-Y, Taran F-A, Fehm T et al (2016) Pooled analysis of the prognostic relevance of circulating tumor cells in primary breast cancer. Clin Cancer Res 22:2583–2593
Gorges TM, Kuske A, Röck K, Mauermann O, Müller V, Peine S et al (2016) Accession of tumor heterogeneity by multiplex transcriptome profiling of single circulating tumor cells. Clin Chem 62:1504–1515
Cayrefourcq L, Mazard T, Joosse S, Solassol J, Ramos J, Assenat E et al (2015) Establishment and characterization of a cell line from human circulating colon cancer cells. Cancer Res 75:892–901
Heitzer E, Ulz P, Geigl JB, Speicher MR (2016) Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies. Mol. Oncol 10:494–502
Heitzer E, Auer M, Hoffmann EM, Pichler M, Gasch C, Ulz P et al (2013) Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer. Int J Cancer 133:346–356
Mohan S, Heitzer E, Ulz P, Lafer I, Lax S, Auer M et al (2014) Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing. PLoS Genet 10:e1004271
Ulz P, Thallinger GG, Auer M, Graf R, Kashofer K, Jahn SW et al (2016) Inferring expressed genes by whole-genome sequencing of plasma DNA. Nat Genet 48:1273–1278
Coffelt SB, Kersten K, Doornebal CW, Weiden J, Vrijland K, Hau C-S et al (2015) IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature 522:345–348
Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X et al (2016) Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell 30:243–256
Hou J, Zhou Y, Zheng Y, Fan J, Zhou W, Ng IO et al (2014) Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma. Cancer Cell 25:49–63
Welm AL, Sneddon JB, Taylor C, D.S.A. Nuyten, van de Vijver MJ, Hasegawa BH et al (2007) The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci 104:7570–7575
Eyob H, Ekiz HA, Derose YS, Waltz SE, Williams MA, Welm AL (2013) Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. Cancer Discov 3:751–760
Davalos AR, Coppe J-P, Campisi J, Desprez P-Y (2010) Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev 29:273–283
Powell E, Shao J, Yuan Y, Chen H-C, Cai S, Echeverria GV et al (2016) p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer. Breast Cancer Res 18:13
Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN et al (2016) Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proc Natl Acad Sci U S A 113:E854–E863
Friedl P, Locker J, Sahai E, Segall JE (2012) Classifying collective cancer cell invasion. Nat Cell Biol 14:777–783
Denais CM, Gilbert RM, Isermann P, McGregor AL, te Lindert M, Weigelin B et al (2016) Nuclear envelope rupture and repair during cancer cell migration. Science 352:353–358
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E et al (2015) Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520:373–377
Duong CPM, Yong CSM, Kershaw MH, Slaney CY, Darcy PK (2015) Cancer immunotherapy utilizing gene-modified T cells: from the bench to the clinic. Mol Immunol 67:46–57
Yong CSM, John LB, Devaud C, Prince MH, Johnstone RW, Trapani JA et al (2016) A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer. Oncotarget 7:34582–34598
You J, Chang R, Liu B, Zu L, Zhou Q (2016) Nm23-H1 was involved in regulation of KAI1 expression in high-metastatic lung cancer cells L9981. J Thorac Dis 8:1217–1226
You J, Zhang Y, Li Y, Fang N, Liu B, Zu L et al (2015) MiR-449a suppresses cell invasion by inhibiting MAP2K1 in non-small cell lung cancer. Am J Cancer Res 5:2730–2744
Li Y, Chen P, Zu L, Liu B, Wang M, Zhou Q (2016) MicroRNA-338-3p suppresses metastasis of lung cancer cells by targeting the EMT regulator Sox4. Am J Cancer Res 6:127–140
Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G et al (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 18:883–891
Hoshino A, Costa-Silva B, Shen T-L, Rodrigues G, Hashimoto A, Tesic Mark M et al (2015) Tumour exosome integrins determine organotropic metastasis. Nature 527:329–335
Hoshino D, Kirkbride KC, Costello K, Clark ES, Sinha S, Grega-Larson N et al (2013) Exosome secretion is enhanced by invadopodia and drives invasive behavior. Cell Rep 5:1159–1168
Sung BH, Ketova T, Hoshino D, Zijlstra A, Weaver AM (2015) Directional cell movement through tissues is controlled by exosome secretion. Nat Commun 6:7164
Di Vizio D, Kim J, Hager MH, Morello M, Yang W, Lafargue CJ et al (2009) Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res 69:5601–5609
Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S et al (2012) Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol 181:1573–1584
Li J, Yang X, Guan H, Mizokami A, Keller ET, Xu X et al (2016) Exosome-derived microRNAs contribute to prostate cancer chemoresistance. Int J Oncol 49:838–846
Ma L, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449:682–688
Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J et al (2014) miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet 10:e1004177
Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J et al (2014) ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol 16:864–875
Liu B, Sun L, Liu Q, Gong C, Yao Y, Lv X et al (2015) A cytoplasmic NF-κB Interacting long noncoding RNA Blocks IκB phosphorylation and suppresses breast cancer metastasis. Cancer Cell 27:370–381
Huang W, Cui X, Chen J, Feng Y, Song E, Li J et al (2016) Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition. Oncotarget 7:62520
Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang W-C et al (2015) Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527:100–104
Qian B-Z, Li J, Zhang H, Kitamura T, Zhang J, Campion LR et al (2011) CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475:222–225
Qian B-Z, Zhang H, Li J, He T, Yeo E-J, Soong DYH et al (2015) FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med 212:1433–1448
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have no conflicts of interest to declare.
Rights and permissions
About this article
Cite this article
Bankaitis, K., Borriello, L., Cox, T. et al. Meeting report: Metastasis Research Society–Chinese Tumor Metastasis Society joint conference on metastasis. Clin Exp Metastasis 34, 203–213 (2017). https://doi.org/10.1007/s10585-017-9842-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10585-017-9842-1