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Adenosine 5′-Triphosphate (ATP) Inhibits Schwann Cell Demyelination During Wallerian Degeneration

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Abstract

Adenosine 5′-triphosphate (ATP) is implicated in intercellular communication as a neurotransmitter in the peripheral nervous system. In addition, ATP is known as lysosomal exocytosis activator. In this study, we investigated the role of extracellular ATP on demyelination during Wallerian degeneration (WD) using ex vivo and in vivo nerve degeneration models. We found that extracellular ATP inhibited myelin fragmentation and axonal degradation during WD. Furthermore, metformin and chlorpromazine, lysosomal exocytosis antagonists blocked the effect of ATP on the inhibition of demyelination. Thus, these findings indicate that ATP-induced-lysosomal exocytosis may be involved in demyelination during WD.

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Acknowledgments

This work was supported by the Dong-A University research fund.

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The authors claim no conflict interests.

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Authors and Affiliations

  1. Department of Anatomy and Neurobiology, School of Medicine, Biomedical Science Institute, Kyung Hee University, Heogi-Dong 1, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea

    Youn Ho Shin, Chan Park & Junyang Jung

  2. Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan, 602-703, Republic of Korea

    Hyung-Joo Chung

  3. Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan, 602-714, Republic of Korea

    Na Young Jeong

Authors
  1. Youn Ho Shin
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  2. Hyung-Joo Chung
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  3. Chan Park
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  4. Junyang Jung
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  5. Na Young Jeong
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Corresponding authors

Correspondence to Junyang Jung or Na Young Jeong.

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Shin, Y.H., Chung, HJ., Park, C. et al. Adenosine 5′-Triphosphate (ATP) Inhibits Schwann Cell Demyelination During Wallerian Degeneration. Cell Mol Neurobiol 34, 361–368 (2014). https://doi.org/10.1007/s10571-013-0020-y

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  • DOI: https://doi.org/10.1007/s10571-013-0020-y

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