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Regenerative medicine improve neurodegenerative diseases

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Abstract

Regenerative medicine is a subdivision of medicine that improves methods to regrow, repair or replace unhealthy cells and tissues to return to normal function. Cell therapy, gene therapy, nanomedicine as choices used to cure neurodegenerative disease. Recently, studies related to the treatment of neurodegenerative disorders have been focused on stem cell therapy and Nano-drugs beyond other than regenerative medicine. Hence, by data from experimental models and clinical trials, we review the impact of stem cell therapy, gene therapy, and nanomedicine on the treatment of Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic lateral sclerosis (ALS). Indeed, improved knowledge and continued research on gene therapy and nanomedicine in treating Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis lead to advancements in effective and practical treatments for neurodegenerative diseases.

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Abbreviations

AD:

Alzheimer’s disease

PD:

Parkinson’s disease

ALS:

Amyotrophic lateral sclerosis

BDNF:

Brain-derived neurotrophic factor

NGF:

Nerve growth factor

DA:

Dopaminergic neuron

NSCs:

Neural stem cells

ESCs:

Embryonic stem cells

VEGF:

Vascular endothelial cell growth factor

AAV:

Adeno-associated virus

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Acknowledgements

We thank the Department of Biology, Science and Research Branch of Islamic Azad University, and the Cellular and Molecular Research Center of Iran University of medical science for their Support.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Seyedeh Sara Ashraf & Ghazaleh Larijani

  2. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

    Seyedeh Sara Ashraf, Vahid Hosseinpour Sarmadi, Ghazaleh Larijani, Seyedeh Lena Mohebi, Nooshin Ahmadirad & Naser Amini

  3. Institutes of Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran

    Seyedeh Sara Ashraf, Vahid Hosseinpour Sarmadi, Seyedeh Lena Mohebi, Peiman Brouki Milan & Naser Amini

  4. Burn Research Center, Iran University of Medical Sciences, Tehran, Iran

    Soheila Naderi Garahgheshlagh

  5. Neuroscience Research Center, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran

    Sara Ramezani

  6. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

    Vahid Hosseinpour Sarmadi, Peiman Brouki Milan & Seyed Mohammad Amin Haramshahi

  7. Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran

    Soraya Moghadamifar

  8. Department of Plastic and Reconstructive surgery, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Soheila Naderi Garahgheshlagh & Seyed Mohammad Amin Haramshahi

  9. Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran

    Sara Ramezani

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  1. Seyedeh Sara Ashraf
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Contributions

NA, NA And SA had the original idea, wrote initial topics and headlines and the first draft. GhL, SN, BD, LM, and PM participated in the writing, editing, and final revising of the manuscript. VS, MJ, and MD supervised the findings of this work. All authors discussed the results and contributed to the final manuscript.

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Correspondence to Nooshin Ahmadirad or Naser Amini.

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Ashraf, S.S., Hosseinpour Sarmadi, V., Larijani, G. et al. Regenerative medicine improve neurodegenerative diseases. Cell Tissue Bank 24, 639–650 (2023). https://doi.org/10.1007/s10561-022-10062-0

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