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New perspective on fatigue in hemodialysis patients with preserved ejection fraction: diastolic dysfunction

Fatigue and diastolic dysfunction

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Abstract

The relationship between diastolic dysfunction and fatigue in hemodialysis patients with preserved ejection fraction is unknown. In this context, the objective of this study is to assess fatigue using the relevant scales and to demonstrate its relationship with diastolic dysfunction. The patients who underwent hemodialysis were evaluated prospectively. Patients’ fatigue was assessed using the Visual Analogue Scale to Evaluate Fatigue Severity (VAS-F). The echocardiographic works were performed as recommended in the American Society of Echocardiography guidelines. A total of 94 patients [mean age 64.7 ± 13.5 years, 54 males (57.4%)] were included in the study. The median VAS-F score of these patients was 68.5 (33.25–91.25), and they were divided into two groups according to this value. Peak myocardial velocities during early diastole (e′) and tricuspid annular plane systolic excursion (TAPSE) values were found to be significantly lower in the group with high VAS-F scores, whereas the early diastolic flow velocities (E)/e′ ratio and pulmonary artery peak systolic pressures (PAP) were found to be significantly higher (p < 0.05, for all). E/e′ ratio (r 0.311, p 0.002) and PAP (r 0.281, p 0.006) values were found to be positively correlated with the VAS-F score, as opposed to the TAPSE (r − 0.257, p 0.012) and e′ (r − 0.303, p 0.003) values, which were found to be negatively correlated with the VAS-F score. High fatigue scores in hemodialysis patients may be associated with diastolic dysfunction. In addition, in our study, we determined the correlation of VAS-F score with E/e′ ratio, PAP and TAPSE.

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Acknowledgements

The authors thank the employees of Baskent University Alanya Application and Research Center HD Unit and Mehmet Atalay, the responsible physician of the HD unit.

Funding

This study was approved by Baskent University Institutional Review Board and Ethics Committee (Project no: KA21/380) and supported by Baskent University Research Fund.

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Authors and Affiliations

  1. Department of Cardiology, Alanya Medical and Research Center, Baskent University Hospital, Saray Mahallesi Yunus Emre Caddesi No: 1, 07400, Alanya, Turkey

    Ertan Akbay, Sinan Akinci, Ali Coner & Adem Adar

  2. Department of Nephrology, Alanya Medical and Research Center, Baskent University Hospital, Alanya, Turkey

    Gultekin Genctoy

  3. Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey

    Ali Riza Demir

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  1. Ertan Akbay
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Correspondence to Ertan Akbay.

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Akbay, E., Akinci, S., Coner, A. et al. New perspective on fatigue in hemodialysis patients with preserved ejection fraction: diastolic dysfunction. Int J Cardiovasc Imaging 38, 2143–2153 (2022). https://doi.org/10.1007/s10554-022-02609-9

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  • DOI: https://doi.org/10.1007/s10554-022-02609-9

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