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Predicting pulmonary hypertension in sarcoidosis; value of PH probability on echocardiography

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Abstract

Pulmonary hypertension (PH) is a well-recognised complication of sarcoidosis. Non-invasive diagnosis is challenging due to limited accuracy of echocardiography in interstitial lung disease. This study evaluates the value of echocardiographic PH probability for diagnosing PH in pulmonary sarcoidosis. All consecutive patients between August 2015 and November 2018 were prospectively screened for PH, and classified as low, intermediate or high PH probability. Patients with intermediate or high PH probability were referred for right heart catheterisation. PH was defined as a mean pulmonary artery pressure of ≥ 25 mm Hg. Additional data on pulmonary function and chest-CT was collected. Of all 479 patients, PH was present in 17 and absent in 19 patients. Six patients refused right heart catheterisation. PH was present in 33% and 75% of patients with intermediate and high PH probability respectively (n = 36). TRV max was measurable in 46% of all patients. Measurability did not correlate with FVC% predicted or presence of significant fibrosis. In intermediate and high PH probability, TRV max < 2.9 m/s successfully ruled out PH whereas a TRV max > 3.4 confirmed PH in all patients. If TRV max was absent or in between 2.9 and 3.4, secondary echocardiographic signs were not able to improve the diagnostic accuracy. PH is unlikely in patients with a TRV max < 2.9 m/s on echocardiography, whereas PH is highly suspected in a TRV max > 3.4 m/s. Discrimination is challenging if the TRV max is between 2.9–3.4 m/s or absent. Additional secondary signs do not improve discrimination. Decision making for further investigations should be made by an expert team.

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Acknowledgements

This study was funded by ZonMW topzorg (project number 842001006). Statistical analysis was performed together with Dr. H. Kelder, epidemiologist. F. Smits, radiologist, scored the presence of fibrosis on chest-CT and reviewed the chest X-ray’s.

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Authors and Affiliations

  1. Department of Cardiology, St. Antonius Hospital Nieuwegein, Koekoekslaan 1, Nieuwegein, 3435, The Netherlands

    M. P. Huitema, A. L. M. Bakker, B. J. W. M. Rensing, M. J. Swaans & M. C. Post

  2. Department of Pulmonology, St. Antonius Hospital Nieuwegein, Koekoekslaan 1, Nieuwegein, 3435, The Netherlands

    J. J. Mager, R. J. Snijder & J. C. Grutters

  3. Department of Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands

    J. C. Grutters

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  1. M. P. Huitema
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  2. A. L. M. Bakker
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  4. R. J. Snijder
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  8. M. C. Post
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Correspondence to M. P. Huitema.

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Huitema, M.P., Bakker, A.L.M., Mager, J.J. et al. Predicting pulmonary hypertension in sarcoidosis; value of PH probability on echocardiography. Int J Cardiovasc Imaging 36, 1497–1505 (2020). https://doi.org/10.1007/s10554-020-01859-9

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  • DOI: https://doi.org/10.1007/s10554-020-01859-9

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