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Comparison of quantitative flow ratio value of left anterior descending and circumflex coronary artery in patients with Takotsubo syndrome

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Abstract

Takotsubo syndrome (TTS) is an acute cardiac event without epicardial coronary obstruction but often with reversible ventricular motion abnormalities. Quantitative flow ratio (QFR) is a novel approach to evaluate the coronary stenosis significance on the basis of 3-dimensional quantitative coronary angiography (3D-QCA) and contrast flow by Thrombolysis in Myocardial Infarction frame count. This study aimed to evaluate and compare the QFR value in the left anterior descending artery (LAD) and the left circumflex artery (LCx) in patients with TTS. This retrospective and observational study enrolled 30 patients with TTS who underwent coronary angiography. We evaluated the QFR data using the 3D-QCA analysis and compared the QFR data in the LAD and the LCx. No significant differences were observed in terms of flow velocity, percent diameter stenosis, minimum lumen diameter, and reference diameter between LAD and LCx. However, vessel QFR in the LAD was significantly reduced compared with that in the LCx (0.98 [0.94 to 0.99] vs. 1.00 [0.99 to 1.00], P < 0.001). Ejection fraction at baseline and initial troponin-I levels were not correlated with the vessel QFR both in the LAD and the LCx. The QFR value in the LAD was significantly reduced compared to that in the LCx in patients with TTS.

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Authors and Affiliations

  1. Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA

    Yuichi Ozaki, Kayode O. Kuku, Alexandre Hideo-Kajita, Ron Waksman & Hector M. Garcia-Garcia

  2. MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, Washington, DC, USA

    Yuichi Ozaki, Kayode O. Kuku, Alexandre Hideo-Kajita & Hector M. Garcia-Garcia

  3. Interventional Cardiology, IdISSC, Hospital Clinico San Carlos, Madrid, Spain

    Nieves Gonzalo, Carlos Hernando Salazar, Hernán Mejía-Rentería, Iván J. Núñez-Gil & Javier Escaned

  4. Section of Interventional Cardiology, MedStar Washington Hospital Center, 110 Irving Street NW, Suite 4B-1, Washington, DC, 20010, USA

    Hector M. Garcia-Garcia

Authors
  1. Yuichi Ozaki
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  2. Nieves Gonzalo
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  3. Carlos Hernando Salazar
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  4. Kayode O. Kuku
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  5. Hernán Mejía-Rentería
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  6. Alexandre Hideo-Kajita
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  7. Iván J. Núñez-Gil
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  8. Javier Escaned
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  9. Ron Waksman
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  10. Hector M. Garcia-Garcia
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Corresponding author

Correspondence to Hector M. Garcia-Garcia.

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Conflict of interest

Ron Waksman: Advisory Board: Abbott Vascular, Amgen, Boston Scientific, Medtronic, Philips Volcano, Pi-Cardia LTD, Cardioset; Consultant: Abbott Vascular, Amgen, Biosensors, Biotronik, Boston Scientific, Medtronic, Philips Volcano, Pi-Cardia LTD, Cardioset; Grant Support: Abbott Vascular, AstraZeneca, Biosensors, Biotronik, Boston Scientific, Chiesi; Speakers Bureau: AstraZeneca, Chiesi; Investor: MedAlliance. All other authors report that they have no relationships relevant to the content of this paper to disclose.

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10554_2019_1703_MOESM1_ESM.docx

Supplementary material 1 Supplemental Figure 1. Description of the relationship among QFR, FFR, MVD for our hypothesis. FFR, fractional flow reserve; MVD, microvascular dysfunction; QFR, quantitative flow ratio. Supplemental Figure 2. Flow chart of this study. QFR, quantitative flow ratio (DOCX 72 kb)

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Ozaki, Y., Gonzalo, N., Salazar, C.H. et al. Comparison of quantitative flow ratio value of left anterior descending and circumflex coronary artery in patients with Takotsubo syndrome. Int J Cardiovasc Imaging 36, 3–8 (2020). https://doi.org/10.1007/s10554-019-01703-9

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  • DOI: https://doi.org/10.1007/s10554-019-01703-9

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