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Relationship of basal-septal fibrosis with LV outflow tract obstruction in hypertrophic cardiomyopathy: insights from cardiac magnetic resonance analysis

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Abstract

Myocardial fibrosis is frequently observed and may be associated with the prognosis in patients with hypertrophic cardiomyopathy (HCM); however, the clinical pathophysiological features, particularly in terms of fibrosis, of hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. This study aimed to determine a role of local fibrosis in HOCM using cardiac magnetic resonance (CMR). 108 consecutive HCM patients underwent CMR. HOCM was defined as a left ventricular outflow tract (LVOT) pressure gradient ≥30 mmHg at rest. Myocardial mass and fibrosis mass by late gadolinium-enhancement CMR (LGE-CMR) were calculated and the distribution/pattern was analyzed using the AHA 17-segment model. LV ejection fraction (LVEF) was significantly higher in patients with HOCM (n = 19) than in those with nonobstructive HCM (n = 89) (P < 0.05). Both total myocardial and fibrosis masses in LV were similar in the two groups (P = 0.385 and P = 0.859, respectively). However, fibrosis in the basal septum was significantly less frequent in the HOCM group than in the nonobstructive HCM group (P < 0.01). The LVOT pressure gradient was significantly higher in the basal-septal non-fibrosis group than in the fibrosis group (23.6 ± 37.3 vs. 4.8 ± 11.4 mmHg, P < 0.01). Multivariate analysis revealed that basal-septal fibrosis was an independent negative predictor of LVOT obstruction in addition to the local wall thickness and LVEF as positive predictors in HCM patients. In conclusion, a significant association was observed between LVOT obstruction and basal septal fibrosis by LGE-CMR in HCM patients. In addition to negative impact of basal-septal fibrosis, basal-septal hypertrophy and preserved global LV contractility may be associated with the pathophysiological features of LVOT obstruction.

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Acknowledgments

This work was supported, in part, by a Grants-in-aid from the Japan Society of the promotion of science (22590815).

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Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511, Japan

    Takashi Nakamura, Yoshitaka Iwanaga, Masakazu Yasuda, Takayuki Kawamura, Yuki Miyaji, Hanako Morooka & Shunichi Miyazaki

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  1. Takashi Nakamura
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  2. Yoshitaka Iwanaga
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  3. Masakazu Yasuda
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  4. Takayuki Kawamura
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Correspondence to Yoshitaka Iwanaga.

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Nakamura, T., Iwanaga, Y., Yasuda, M. et al. Relationship of basal-septal fibrosis with LV outflow tract obstruction in hypertrophic cardiomyopathy: insights from cardiac magnetic resonance analysis. Int J Cardiovasc Imaging 32, 613–620 (2016). https://doi.org/10.1007/s10554-015-0806-8

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  • DOI: https://doi.org/10.1007/s10554-015-0806-8

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