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Cardiac magnetic resonance imaging characteristics of isolated left ventricular noncompaction in a Chinese adult Han population

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Abstract

To analyze cardiac magnetic resonance imaging (CMR) characteristics in patients with isolated left ventricular noncompaction (IVNC) and assess its value in the diagnosis of IVNC in a Chinese adult Han population. We collected a consecutive series of 30 patients with IVNC from January 1, 2007, to December 31, 2008. During the same period, we prospectively included patients drawn from groups given a potential differential diagnosis for IVNC. All magnetic resonance images were analyzed using 17-segment model. Left ventricular ejection fraction was significantly lower for patients with DCM (16.2 ± 5.2%, P < 0.001) and higher in AR (47.6 ± 16.2%, P = 0.009), AS (54.6 ± 21.1%, P = 0.001) and HHD (62.4 ± 6.8%, P < 0.001) compared with IVNC (33.0 ± 14.1%). The two-layered structure was most frequently seen at the apical segments, followed by the mid-cavity and basal segments in patients with INVC. The anterior and lateral walls were more commonly involved in patients with IVNC. The number of noncompacted segments and end-diastolic ratio of non-compacted to compacted myocardium (NC/C ratio) was greater in patients with IVNC than in other five groups. The end-diastolic NC/C ratio of >2.5 had 96.4% sensitivity and 97.4% specificity for identifying patients with IVNC. CMR provides an accurate and reliable evaluation of the localization and extent of noncompacted myocardium at end-diastole. The end-diastolic NC/C ratio of >2.5 had high diagnostic accuracy for IVNC in a Chinese adult Han population.

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References

  1. Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R (1990) Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation 82:507–513

    Article  PubMed  CAS  Google Scholar 

  2. Stöllberger C, Finsterer J, Blazek G (2002) Left ventricular hypertrabeculation/noncompaction and association with additional cardiac abnormalities and neuromuscular disorders. Am J Cardiol 90:899–902

    Article  PubMed  Google Scholar 

  3. Ichida F, Hamamichi Y, Miyawaki T, Ono Y, Kamiya T, Akagi T, Hamada H, Hirose O, Isobe T, Yamada K, Kurotobi S, Mito H, Miyake T, Murakami Y, Nishi T, Shinohara M, Seguchi M, Tashiro S, Tomimatsu H (1999) Clinical features of isolated noncompaction of the ventricular myocardium: long-term clinical course, hemodynamic properties, and genetic background. J Am Coll Cardiol 34:233–240

    Article  PubMed  CAS  Google Scholar 

  4. Oechslin EN, Attenhofer Jost CH, Rojas JR, Kaufmann PA, Jenni R (2000) Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol 36:493–500

    Article  PubMed  CAS  Google Scholar 

  5. Ritter M, Oechslin E, Sütsch G, Attenhofer C, Schneider J, Jenni R (1997) Isolated noncompaction of the myocardium in adults. Mayo Clin Proc 72:26–31

    Article  PubMed  CAS  Google Scholar 

  6. Murphy RT, Thaman R, Blanes JG, Ward D, Sevdalis E, Papra E, Kiotsekoglou A, Tome MT, Pellerin D, McKenna WJ, Elliott PM (2005) Natural history and familial characteristics of isolated left ventricular non-compaction. Eur Heart J 26:187–192

    Article  PubMed  Google Scholar 

  7. Jenni R, Oechslin EN, van der Loo B (2007) Isolated ventricular non-compaction of the myocardium in adults. Heart 93:11–15

    Article  PubMed  CAS  Google Scholar 

  8. Pignatelli RH, McMahon CJ, Dreyer WJ, Denfield SW, Price J, Belmont JW, Craigen WJ, Wu J, El Said H, Bezold LI, Clunie S, Fernbach S, Bowles NE, Towbin JA (2003) Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation 108:2672–2678

    Article  PubMed  Google Scholar 

  9. Kohli SK, Pantazis AA, Shah JS, Adeyemi B, Jackson G, McKenna WJ, Sharma S, Elliott PM (2008) Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria? Eur Heart J 29:89–95

    Article  PubMed  Google Scholar 

  10. Frischknecht BS, Attenhofer Jost CH, Oechslin EN, Seifert B, Hoigné P, Roos M, Jenni R (2005) Validation of noncompaction criteria in dilated cardiomyopathy, and valvular and hypertensive heart disease. J Am Soc Echocardiogr 18:865–872

    Article  PubMed  Google Scholar 

  11. Tamborini G, Pepi M, Celeste F, Muratori M, Susini F, Maltagliati A, Veglia F (2004) Incidence and characteristics of left ventricular false tendons and trabeculations in the normal and pathologic heart by second harmonic echocardiography. J Am Soc Echocardiogr 17:367–374

    Article  PubMed  Google Scholar 

  12. Jenni R, Oechslin E, Schneider J, Attenhofer Jost C, Kaufmann PA (2001) Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy. Heart 86:666–671

    Article  PubMed  CAS  Google Scholar 

  13. Petersen SE, Selvanayagam JB, Wiesmann F, Robson MD, Francis JM, Anderson RH, Watkins H, Neubauer S (2005) Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol 46:101–105

    Article  PubMed  Google Scholar 

  14. Jacquier A, Thuny F, Jop B, Giorgi R, Cohen F, Gaubert JY, Vidal V, Bartoli JM, Habib G, Moulin G (2010) Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction. Eur Heart J 31:1098–1104

    Article  PubMed  Google Scholar 

  15. Sahin S, Karsidag S (2009) An unusual cause of cardioembolic stroke: isolated left ventricular noncompaction. Neurologist 15(1):51

    Article  PubMed  Google Scholar 

  16. Fan H, Zheng Z, Feng W, Zhang Y, Jin L, Li P, Hu S (2010) Apical conicity ratio: a new index on left ventricular apical geometry after myocardial infarction. J Thorac Cardiovasc Surg. doi: 10.1016/j.jtcvs.2010.02.017

  17. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging 18:539–542

    PubMed  Google Scholar 

  18. Aras D, Tufekcioglu O, Ergun K, Ozeke O, Yildiz A, Topaloglu S, Deveci B, Sahin O, Kisacik HL, Korkmaz S (2006) Clinical features of isolated ventricular noncompaction in adults long-term clinical course, echocardiographic properties, and predictors of left ventricular failure. J Card Fail 12:726–733

    Article  PubMed  Google Scholar 

  19. Finsterer J, Stöllberger C, Schubert B (2004) Acquired left ventricular hypertrabeculation/noncompaction in mitochondriopathy. Cardiology 102:228–230

    Article  PubMed  Google Scholar 

  20. Finsterer J, Stöllberger C, Wegmann R, Janssen LA (2009) Acquired left ventricular hypertrabeculation/noncompaction in myotonic dystrophy type 1. Int J Cardiol 137:310–313

    Article  PubMed  CAS  Google Scholar 

  21. Hamamichi Y, Ichida F, Hashimoto I, Uese KH, Miyawaki T, Tsukano S, Ono Y, Echigo S, Kamiya T (2001) Isolated noncompaction of the ventricular myocardium: ultrafast computed tomography and magnetic resonance imaging. Int J Cardiovasc Imaging 17:305–314

    Article  PubMed  CAS  Google Scholar 

  22. Sengupta PP, Mohan JC, Mehta V, Jain V, Arora R, Pandian NG, Khandheria BK (2004) Comparison of echocardiographic features of noncompaction of the left ventricle in adults versus idiopathic dilated cardiomyopathy in adults. Am J Cardiol 94:389–391

    Article  PubMed  Google Scholar 

  23. Alhabshan F, Smallhorn JF, Golding F, Musewe N, Freedom RM, Yoo SJ (2005) Extent of myocardial non-compaction: comparison between MRI and echocardiographic evaluation. Pediatr Radiol 35:1147–1151

    Article  PubMed  Google Scholar 

  24. Thuny F, Jacquier A, Jop B, Giorgi R, Gaubert JY, Bartoli JM, Moulin G, Habib G (2010) Assessment of left ventricular non-compaction in adults: side-by-side comparison of cardiac magnetic resonance imaging with echocardiography. Arch Cardiovasc Dis 103:150–159

    Article  PubMed  Google Scholar 

  25. Stöllberger C, Finsterer J (2010) A diagnostic dilemma in non-compaction, resulting in near expulsion from the football world cup. Eur J Echocardiogr. doi: 10.1093/ejechocard/jeq110

  26. Fazio G, Novo G, D’Angelo L, Visconti C, Sutera L, Grassedonio E, Galia M, Ferrara F, Midiri M, Novo S (2010) Magnetic resonance in isolated noncompaction of the ventricular myocardium. Int J Cardiol 140(3):367–369

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors express their heartfelt gratitude to the staff and members of the department of radiology, department of echocardiography and division of cardiology for their assistance in various measurements, diagnosis and other organizational aspects of this study. This work was supported in part by grants No. 30670609 and 81071199 from the National Natural Science Foundation of China, by grant No. 20050023042 from Research Fund for the Doctoral Program of Higher Education of China and by grant No. 2009-1004 from Research Foundation of Capital Medical Development.

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Authors and Affiliations

  1. Department of Radiology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, 100037, Beijing, China

    Huaibing Cheng, Shihua Zhao, Shiliang Jiang, Jinchao Yu, Minjie Lu, Jian Ling, Yan Zhang, Chaowu Yan, Qiong Liu & Shiguo Li

  2. Department of Nuclear medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China

    Zuoxiang He

  3. Collaboration Team, Siemens Ltd, Shanghai, China

    Lixin Jin

  4. MR Research and Development, Siemens Medical Solutions USA, Inc., Chicago, IL, USA

    Renate Jerecic

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  1. Huaibing Cheng
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  2. Shihua Zhao
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  3. Shiliang Jiang
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Correspondence to Shihua Zhao.

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Cheng, H., Zhao, S., Jiang, S. et al. Cardiac magnetic resonance imaging characteristics of isolated left ventricular noncompaction in a Chinese adult Han population. Int J Cardiovasc Imaging 27, 979–987 (2011). https://doi.org/10.1007/s10554-010-9741-x

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  • DOI: https://doi.org/10.1007/s10554-010-9741-x

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