Skip to main content
SpringerLink
Log in

Plaque burden, plaque morphology, and HDL: can atherosclerosis imaging provide insights into the complex, multifactorial etiology of atherosclerosis progression and vulnerability?

  • Editorial Comment
  • Published:
The International Journal of Cardiovascular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Phan BAP, Chu B, Polissar N, Hatsukami TS, Yuan C, Zhao XQ. Association of high density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imaging (2006) CAIM

  2. Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ (2001) Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 345:1583–1592

    Article  PubMed  CAS  Google Scholar 

  3. Libby P, Theroux P (2005) Pathophysiology of coronary artery disease. Circulation 111:3481–3488

    Article  PubMed  Google Scholar 

  4. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) (2001) JAMA 285:2486–2497

  5. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F; Centers for Disease Control and Prevention; American Heart Association (2003) Markers of inflammation and cardiovascular disease: application to clinical and public health practice. A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107:499–511

    Google Scholar 

  6. Nissen SE, Tuzcu EM, Schoenhagen P, Brown BG, Ganz P, Vogel RA, Crowe T, Howard G, Cooper CJ, Brodie B, Grines CL, DeMaria AN (2004) REVERSAL Investigators. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA 291:1071–1080

    Article  PubMed  CAS  Google Scholar 

  7. Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, Schoenhagen P, Crowe T, Cain V, Wolski K, Goormastic M, Tuzcu EM (2006) ASTEROID Investigators. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 295:1556–1565

    Article  PubMed  CAS  Google Scholar 

  8. Corti R, Fuster V, Fayad ZA, Worthley SG, Helft G, Chaplin WF, Muntwyler J, Viles-Gonzalez JF, Weinberger J, Smith DA, Mizsei G, Badimon JJ (2005) Effects of aggressive versus conventional lipid-lowering therapy by simvastatin on human atherosclerotic lesions: a prospective, randomized, double-blind trial with high-resolution magnetic resonance imaging. J Am Coll Cardiol 46:106–112

    Article  PubMed  CAS  Google Scholar 

  9. Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, Eaton GM, Lauer MA, Sheldon WS, Grines CL, Halpern S, Crowe T, Blankenship JC, Kerensky R (2003) Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA 290:2292–2300

    Article  PubMed  CAS  Google Scholar 

  10. Schartl M, Bocksch W, Koschyk DH, Voelker W, Karsch KR, Kreuzer J, Hausmann D, Beckmann S, Gross M (2001) Use of intravascular ultrasound to compare effects of different strategies of lipid-lowering therapy on plaque volume and composition in patients with coronary artery disease. Circulation. 104:387–392

    PubMed  CAS  Google Scholar 

  11. Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG (2002) Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 106:2200–2206

    Article  PubMed  Google Scholar 

  12. Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J, Orazem J, Magorien RD, O’Shaughnessy C, Ganz P (2005) Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 352:29–38

    Article  PubMed  CAS  Google Scholar 

  13. Schoenhagen P, Tuzcu EM, Apperson-Hansen C, Wang C, Wolski K, Lin S, Sipahi I, Nicholls SJ, Magyar WA, Loyd A, Churchill T, Crowe T, Nissen SE (2006) Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial. Circulation 113:2826–2834

    Article  PubMed  CAS  Google Scholar 

  14. Zhao XQ, Yuan C, Hatsukami TS, Frechette EH, Kang XJ, Maravilla KR, Brown BG (2001) Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study. Arterioscler Thromb Vasc Biol 21:1623–1629

    PubMed  CAS  Google Scholar 

  15. Corti R, Fayad ZA, Fuster V, Worthley SG, Helft G, Chesebro J, Mercuri M, Badimon JJ (2001) Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging.Circulation 104:249–252

    PubMed  CAS  Google Scholar 

  16. Van Mieghem CA, Bruining N, Schaar JA, McFadden E, Mollet N, Cademartiri F, Mastik F, Ligthart JM, Granillo GA, Valgimigli M, Sianos G, van der Giessen WJ, Backx B, Morel MA, Van Es GA, Sawyer JD, Kaplow J, Zalewski A, van der Steen AF, de Feyter P, Serruys PW (2005) Rationale and methods of the integrated biomarker and imaging study (IBIS): combining invasive and non-invasive imaging with biomarkers to detect subclinical atherosclerosis and assess coronary lesion biology. Int J Cardiovasc Imaging 21:425–441

    Article  PubMed  Google Scholar 

  17. Van Mieghem CA, McFadden EP, de Feyter PJ, Bruining N, Schaar JA, Mollet NR, Cademartiri F, Goedhart D, de Winter S, Granillo GR, Valgimigli M, Mastik F, van der Steen AF, van der Giessen WJ, Sianos G, Backx B, Morel MA, van Es GA, Zalewski A, Serruys PW (2006) Noninvasive detection of subclinical coronary atherosclerosis coupled with assessment of changes in plaque characteristics using novel invasive imaging modalities: the Integrated Biomarker and Imaging Study (IBIS). J Am Coll Cardiol 47:1134–1142

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Radiology and Department of Cardiovascular Medicine, The Cleveland Clinic, Desk HB-6, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Paul Schoenhagen

Authors
  1. Paul Schoenhagen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Paul Schoenhagen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schoenhagen, P. Plaque burden, plaque morphology, and HDL: can atherosclerosis imaging provide insights into the complex, multifactorial etiology of atherosclerosis progression and vulnerability?. Int J Cardiovasc Imaging 23, 343–345 (2007). https://doi.org/10.1007/s10554-006-9192-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10554-006-9192-6

Keywords

Search

Navigation