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Colorectal cancer incidence among Hispanics and non-Hispanic Whites in the United States

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Abstract

Purpose

Colorectal cancer (CRC) incidence has declined over the past two decades; however, these declines have not occurred equally in all populations. To better understand the impact of CRC among Hispanics, we examined incidence trends by age and Hispanic ethnicity.

Methods

Using data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program, we estimated CRC incidence rates during the period 2001–2014, and across all 50 U.S. states. We estimated incidence rates in younger (age < 50 years) and older (age ≥ 50 years) adults by anatomic subsite and stage at diagnosis, separately for non-Hispanic Whites and Hispanic Whites.

Results

CRC incidence rates declined among older (age ≥ 50 years) Whites and Hispanics, but Whites experienced a greater decline (31% vs. 27% relative decline among Hispanics). In contrast to older adults, there were continued increases in CRC incidence from 2001 to 2014 among younger (age 20–49 years) adults. The largest relative increases in incidence occurred in Hispanics aged 20–29 years (90% vs. 50% relative increase among Whites).

Conclusions

Opposing incidence trends in younger versus older Hispanics may reflect generational differences in CRC risk by birth cohort, as well as environmental exposures and lifestyle-related risk factors associated with immigration and acculturation.

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Funding

This work was supported by the National Cancer Institute (P30CA142543) and National Center for Advancing Translational Sciences (KL2TR001103 to Dr. Murphy) at the National Institutes of Health.

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Authors and Affiliations

  1. Departments of Clinical Sciences and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Sandra Garcia, Sandi L. Pruitt, Amit G. Singal & Caitlin C. Murphy

  2. Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, USA

    Sandra Garcia, Sandi L. Pruitt, Amit G. Singal & Caitlin C. Murphy

  3. Division of Epidemiology, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA

    Caitlin C. Murphy

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  1. Sandra Garcia
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Correspondence to Caitlin C. Murphy.

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Garcia, S., Pruitt, S.L., Singal, A.G. et al. Colorectal cancer incidence among Hispanics and non-Hispanic Whites in the United States. Cancer Causes Control 29, 1039–1046 (2018). https://doi.org/10.1007/s10552-018-1077-1

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