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Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case–control study

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Abstract

Background

Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC).

Methods

A case–control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case.

Results

Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58–1.62) or GCT (OR 1.13, 95% CI 0.51–2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85–1.43) or GCT (OR 0.93, 95% CI 0.68–1.28).

Conclusions

Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.

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Acknowledgments

This research was supported by the National Cancer Institute at the National Institutes of Health. The funding source had no role in the study design, interpretation of data, and publication of results. This study was conducted while Adetunji T Toriola was at the National Institute for Health and Welfare, Finland. He was supported by a European Association for Cancer Research (EACR) Travel Fellowship Award to visit the Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg. The authors are indebted to Yelena Afanasyeva, Pirjo Kontiokari, Annika Uimonen, and Sara Kuusiniemi for their excellent technical assistance in the conduct of the study.

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Adetunji T. Toriola

  2. National Institute for Health and Welfare, Oulu, Finland

    Helja-Marja Surcel

  3. Department of Medical Biosciences, University of Umeå, Umeå, Sweden

    Eva Lundin & Kjell Grankvist

  4. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

    Helena Schock, Tianhui Chen & Annekatrin Lukanova

  5. Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland

    Eero Pukkala

  6. Tampere School of Public Health, University of Tampere, Tampere, Finland

    Eero Pukkala & Matti Lehtinen

  7. New York University Cancer Institute, New York, NY, USA

    Paolo Toniolo & Anne Zeleniuch-Jacquotte

  8. Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA

    Paolo Toniolo & Annekatrin Lukanova

  9. Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland

    Paolo Toniolo

  10. Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA

    Anne Zeleniuch-Jacquotte

Authors
  1. Adetunji T. Toriola
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  2. Helja-Marja Surcel
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  3. Eva Lundin
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  4. Helena Schock
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  5. Kjell Grankvist
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  6. Eero Pukkala
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  7. Tianhui Chen
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  8. Paolo Toniolo
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  9. Matti Lehtinen
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  10. Anne Zeleniuch-Jacquotte
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  11. Annekatrin Lukanova
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Corresponding author

Correspondence to Adetunji T. Toriola.

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Toriola, A.T., Surcel, HM., Lundin, E. et al. Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case–control study. Cancer Causes Control 22, 1607–1611 (2011). https://doi.org/10.1007/s10552-011-9828-2

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  • DOI: https://doi.org/10.1007/s10552-011-9828-2

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