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Incidence trends of invasive cervical cancer in the United States by combined race and ethnicity

Cancer Causes & Control Aims and scope Submit manuscript

Abstract

Objective

To better understand national patterns of invasive cervical cancer (ICC) incidence by race and ethnicity in order to develop appropriate ICC prevention policies.

Methods

Age-adjusted and age-specific ICC incidence rates were calculated by combined race/ethnicity, making distinct the Hispanic/all races category from three other Non-Hispanic (White, Black and other) racial categories.

Results

There was a significant downward trend in ICC incidence during both time periods for every combination of race/ethnicity (p-value <0.05) except Hispanic/all races during 1995–1999. Non-Hispanic/Black and Hispanic/all races women had significantly higher incidence rates of ICC compared to Non-Hispanic/White women. ICC incidence peaked much earlier for Non-Hispanic/White women (35–44 years of age) compared to any other racial/ethnic group. Non-Hispanic (White, Black and other) women had lower rates of adenocarcinoma and squamous cell carcinoma compared to Hispanic/all races women. Non-Hispanic/Black and Hispanic/all races women were more likely to be diagnosed at late stage or unstaged at diagnosis than Non-Hispanic/White women.

Conclusion

Although ICC incidence decreased significantly over the last 10 years, Black or Hispanic US populations continue to have the highest ICC incidence compared to Non-Hispanic/Whites, highlighting the need for improved health literacy and social support to ensure their equal access to ICC screening and HPV prevention including HPV vaccination.

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References

  1. Global Cancer Facts & Figures, 2007 (2007) American Cancer Society, Inc, Atlanta, GA

  2. Gustafsson L, Ponten J, Zack M, Adami HO (1997) International incidence rates of invasive cervical cancer after introduction of cytological screening. Cancer Causes Control 8:755–763. doi:10.1023/A:1018435522475

    Article  PubMed  CAS  Google Scholar 

  3. Wang SS, Sherman ME, Hildesheim A, Lacey JV Jr, Devesa S (2004) Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000. Cancer 100:1035–1044. doi:10.1002/cncr.20064

    Article  PubMed  Google Scholar 

  4. Ries LAG, Melbert D, Krapcho M et al (2008) SEER cancer statistics review, 1975–2005, based on 11/07 SEER data submission. National Cancer Institute, Bethesda, MD. http://seer.cancer.gov/csr/1975-2005/

  5. Cancer Facts & Figures for Hispanics/Latinos 2006–2008 (2008) American Cancer Society, Inc, Atlanta, GA

  6. Cancer facts & figures for African Americans 2007–2008 (2007) American Cancer Society, Inc, Atlanta, GA

  7. Benard VB, Coughlin SS, Thompson T, Richardson LC (2007) Cervical cancer incidence in the United States by area of residence, 1998–2001. Obstet Gynecol 110:681–686

    PubMed  Google Scholar 

  8. McDougall JA, Madeleine MM, Daling JR, Li CI (2007) Racial and ethnic disparities in cervical cancer incidence rates in the United States, 1992–2003. Cancer Causes Control 18:1175–1186. doi:10.1007/s10552-007-9056-y

    Article  PubMed  Google Scholar 

  9. Saraiya M, Ahmed F, Krishnan S et al (2007) Cervical cancer incidence in a prevaccine era in the United States, 1998–2002. Obstet Gynecol 109:360–370

    PubMed  Google Scholar 

  10. Howe HL, Wu X, Ries LA et al (2006) Annual report to the nation on the status of cancer, 1975–2003, featuring cancer among U.S. Hispanic/Latino populations. Cancer 107:1711–1742. doi:10.1002/cncr.22193

    Article  PubMed  Google Scholar 

  11. Parham GP, Hicks ML (2005) Racial disparities affecting the reproductive health of African-American women. Med Clin North Am 89:935–43, 941

    Google Scholar 

  12. Shavers VL, Brown ML (2002) Racial and ethnic disparities in the receipt of cancer treatment. J Natl Cancer Inst 94:334–357

    PubMed  Google Scholar 

  13. Ward E, Jemal A, Cokkinides V et al (2004) Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin 54:78–93

    Article  PubMed  Google Scholar 

  14. Benard VB, Lee NC, Piper M, Richardson L (2001) Race-specific results of Papanicolaou testing and the rate of cervical neoplasia in the National Breast and Cervical Cancer Early Detection Program, 1991–1998 (United States). Cancer Causes Control 12:61–68. doi:10.1023/A:1008959019019

    Article  PubMed  CAS  Google Scholar 

  15. Munoz N, Bosch FX, de Sanjose S et al (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518–527. doi:10.1056/NEJMoa021641

    Article  PubMed  Google Scholar 

  16. Walboomers JM, Jacobs MV, Manos MM et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189:12–19. doi:10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F

    Article  PubMed  CAS  Google Scholar 

  17. Dunne EF, Unger ER, Sternberg M et al (2007) Prevalence of HPV infection among females in the United States. Jama 297:813–819. doi:10.1001/jama.297.8.813

    Article  PubMed  CAS  Google Scholar 

  18. Schiffman MH, Hildesheim A (2006) Cervical cancer In: Schottenfeld D, Fraumeni J, Editorsin JF (eds) Cancer epidemiology and prevention, 3rd edn. Oxford University Press, New York, pp 1044–1067

  19. Castellsague X, Munoz N (2003) Chapter 3: cofactors in human papillomavirus carcinogenesis—role of parity, oral contraceptives, and tobacco smoking. J Natl Cancer Inst Monogr, 31:20–28

    Google Scholar 

  20. Cancer Prevention and Early Detection Facts & Figures (2008) American Cancer Society, Inc, Atlanta, GA

  21. Devesa SS, Diamond EL (1980) Association of breast cancer and cervical cancer incidence with income and education among whites and blacks. J Natl Cancer Inst 65:515–528

    PubMed  CAS  Google Scholar 

  22. Khan MJ, Partridge EE, Wang SS, Schiffman M (2005) Socioeconomic status and the risk of cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology. Cancer 104:61–70. doi:10.1002/cncr.21129

    Article  PubMed  Google Scholar 

  23. National Center for Health Statistics (2006) Chartbook on trends in the health of Americans. Centers for Disease Control and Prevention, Hyattsville, MD

    Google Scholar 

  24. Watson M, Sariaiya M, Benard V et al (2008) Burden of cervical cancer in the United States, 1998–2003. Cancer 113(10 Suppl):2855–2864. doi:10.1002/cncr.23756

    Article  PubMed  Google Scholar 

  25. Espey DK, Wu XC, Swan J et al (2007) Annual report to the nation on the status of cancer, 1975–2004, featuring cancer in American Indians and Alaska Natives. Cancer 110:2119–2152. doi:10.1002/cncr.23044

    Article  PubMed  Google Scholar 

  26. Zeig-Owens R, Knowlton R, Gershman ST, Howe HL (2007) CINA highlights of cancer incidence and mortality in the United States and Canada, 2000–2004. North American Association of Central Cancer Registries, Inc, Springfield, IL

    Google Scholar 

  27. NAACCR, The North American Association of Central Cancer Registries (NAACCR); www.naaccr.org. 2008: Springfield, IL

  28. SEER*Stat. Verison 6.3.6 (2007) National Cancer Institute, Bethesda, ML

  29. Tiwari RC, Clegg LX, Zou Z (2006) Efficient interval estimation for age-adjusted cancer rates. Stat Methods Med Res 15:547–569. doi:10.1177/0962280206070621

    Article  PubMed  Google Scholar 

  30. Swan J, Breen N, Coates RJ, Rimer BK, Lee NC (2003) Progress in cancer screening practices in the United States: results from the 2000 National Health Interview Survey. Cancer 97:1528–1540. doi:10.1002/cncr.11208

    Article  PubMed  Google Scholar 

  31. Screening for cervical cancer: recommendations and rationale (2003) U.S. Preventive Services Task Force (January 2003). http://www.ahrq.gov/clinic/3rduspstf/carvicalcan/cervcanrr.htm. Cited 26 Feb 2008

  32. Krane JF, Granter SR, Trask CE, Hogan CL, Lee KR (2001) Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases. Cancer 93:8–15. doi:10.1002/1097-0142(20010225)93:1<8::AID-CNCR9001>3.0.CO;2-K

    Article  PubMed  CAS  Google Scholar 

  33. Renshaw AA, Mody DR, Lozano RL et al (2004) Detection of adenocarcinoma in situ of the cervix in Papanicolaou tests: comparison of diagnostic accuracy with other high-grade lesions. Arch Pathol Lab Med 128:153–157

    PubMed  Google Scholar 

  34. Singh GK, Miller BA, Hankey BF, Edwards BK (2004) Persistent area socioeconomic disparities in U.S. incidence of cervical cancer, mortality, stage, and survival, 1975–2000. Cancer 101:1051–1057. doi:10.1002/cncr.20467

    Article  PubMed  Google Scholar 

  35. Henson RM, Wyatt SW, Lee NC (1996) The National Breast and Cervical Cancer Early Detection Program: a comprehensive public health response to two major health issues for women. J Public Health Manag Pract 2:36–47

    PubMed  CAS  Google Scholar 

  36. Benard VB, Eheman CR, Lawson HW et al (2004) Cervical screening in the National Breast and Cervical Cancer Early Detection Program, 1995–2001. Obstet Gynecol 103:564–571

    PubMed  Google Scholar 

  37. Paskett ED, Tatum C, Rushing J et al (2004) Racial differences in knowledge, attitudes, and cancer screening practices among a triracial rural population. Cancer 101:2650–2659. doi:10.1002/cncr.20671

    Article  PubMed  Google Scholar 

  38. Vanslyke JG, Baum J, Plaza V et al (2008) HPV and cervical cancer testing and prevention: knowledge, beliefs, and attitudes among Hispanic women. Qual Health Res 18:584–596. doi:10.1177/1049732308315734

    Article  PubMed  Google Scholar 

  39. Gomez SL, Glaser SL (2006) Misclassification of race/ethnicity in a population-based cancer registry (United States). Cancer Causes Control 17:771–781. doi:10.1007/s10552-006-0013-y

    Article  PubMed  Google Scholar 

  40. Gomez SL, Kelsey JL, Glaser SL, Lee MM, Sidney S (2005) Inconsistencies between self-reported ethnicity and ethnicity recorded in a health maintenance organization. Ann Epidemiol 15:71–79. doi:10.1016/j.annepidem.2004.03.002

    Article  PubMed  Google Scholar 

  41. Stewart SL, Swallen KC, Glaser SL, Horn-Ross PL, West DW (1999) Comparison of methods for classifying Hispanic ethnicity in a population-based cancer registry. Am J Epidemiol 149:1063–1071

    PubMed  CAS  Google Scholar 

  42. Swallen KC, West DW, Stewart SL, Glaser SL, Horn-Ross PL (1997) Predictors of misclassification of Hispanic ethnicity in a population-based cancer registry. Ann Epidemiol 7:200–206. doi:10.1016/S1047-2797(96)00154-8

    Article  PubMed  CAS  Google Scholar 

  43. Lepine LA, Hillis SD, Marchbanks PA et al (1997) Hysterectomy surveillance—United States, 1980–1993. MMWR CDC Surveill Summ 46:1–15

    PubMed  CAS  Google Scholar 

  44. NAACCR (2007) Cancer in North America (CINA) deluxe 1995–2004 database. The North American Association of Central Cancer Registries (NAACCR), Springfield, IL. www.naaccr.org

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Acknowledgments

This work was supported in part through a research grant from the North American Association of Central Cancer Registries (NAACCR) Program to JSB-S.

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Correspondence to Jill Barnholtz-Sloan.

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Barnholtz-Sloan, J., Patel, N., Rollison, D. et al. Incidence trends of invasive cervical cancer in the United States by combined race and ethnicity. Cancer Causes Control 20, 1129–1138 (2009). https://doi.org/10.1007/s10552-009-9317-z

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  • DOI: https://doi.org/10.1007/s10552-009-9317-z

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