Abstract
Objective
To better understand national patterns of invasive cervical cancer (ICC) incidence by race and ethnicity in order to develop appropriate ICC prevention policies.
Methods
Age-adjusted and age-specific ICC incidence rates were calculated by combined race/ethnicity, making distinct the Hispanic/all races category from three other Non-Hispanic (White, Black and other) racial categories.
Results
There was a significant downward trend in ICC incidence during both time periods for every combination of race/ethnicity (p-value <0.05) except Hispanic/all races during 1995–1999. Non-Hispanic/Black and Hispanic/all races women had significantly higher incidence rates of ICC compared to Non-Hispanic/White women. ICC incidence peaked much earlier for Non-Hispanic/White women (35–44 years of age) compared to any other racial/ethnic group. Non-Hispanic (White, Black and other) women had lower rates of adenocarcinoma and squamous cell carcinoma compared to Hispanic/all races women. Non-Hispanic/Black and Hispanic/all races women were more likely to be diagnosed at late stage or unstaged at diagnosis than Non-Hispanic/White women.
Conclusion
Although ICC incidence decreased significantly over the last 10 years, Black or Hispanic US populations continue to have the highest ICC incidence compared to Non-Hispanic/Whites, highlighting the need for improved health literacy and social support to ensure their equal access to ICC screening and HPV prevention including HPV vaccination.
References
Global Cancer Facts & Figures, 2007 (2007) American Cancer Society, Inc, Atlanta, GA
Gustafsson L, Ponten J, Zack M, Adami HO (1997) International incidence rates of invasive cervical cancer after introduction of cytological screening. Cancer Causes Control 8:755–763. doi:10.1023/A:1018435522475
Wang SS, Sherman ME, Hildesheim A, Lacey JV Jr, Devesa S (2004) Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000. Cancer 100:1035–1044. doi:10.1002/cncr.20064
Ries LAG, Melbert D, Krapcho M et al (2008) SEER cancer statistics review, 1975–2005, based on 11/07 SEER data submission. National Cancer Institute, Bethesda, MD. http://seer.cancer.gov/csr/1975-2005/
Cancer Facts & Figures for Hispanics/Latinos 2006–2008 (2008) American Cancer Society, Inc, Atlanta, GA
Cancer facts & figures for African Americans 2007–2008 (2007) American Cancer Society, Inc, Atlanta, GA
Benard VB, Coughlin SS, Thompson T, Richardson LC (2007) Cervical cancer incidence in the United States by area of residence, 1998–2001. Obstet Gynecol 110:681–686
McDougall JA, Madeleine MM, Daling JR, Li CI (2007) Racial and ethnic disparities in cervical cancer incidence rates in the United States, 1992–2003. Cancer Causes Control 18:1175–1186. doi:10.1007/s10552-007-9056-y
Saraiya M, Ahmed F, Krishnan S et al (2007) Cervical cancer incidence in a prevaccine era in the United States, 1998–2002. Obstet Gynecol 109:360–370
Howe HL, Wu X, Ries LA et al (2006) Annual report to the nation on the status of cancer, 1975–2003, featuring cancer among U.S. Hispanic/Latino populations. Cancer 107:1711–1742. doi:10.1002/cncr.22193
Parham GP, Hicks ML (2005) Racial disparities affecting the reproductive health of African-American women. Med Clin North Am 89:935–43, 941
Shavers VL, Brown ML (2002) Racial and ethnic disparities in the receipt of cancer treatment. J Natl Cancer Inst 94:334–357
Ward E, Jemal A, Cokkinides V et al (2004) Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin 54:78–93
Benard VB, Lee NC, Piper M, Richardson L (2001) Race-specific results of Papanicolaou testing and the rate of cervical neoplasia in the National Breast and Cervical Cancer Early Detection Program, 1991–1998 (United States). Cancer Causes Control 12:61–68. doi:10.1023/A:1008959019019
Munoz N, Bosch FX, de Sanjose S et al (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518–527. doi:10.1056/NEJMoa021641
Walboomers JM, Jacobs MV, Manos MM et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189:12–19. doi:10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
Dunne EF, Unger ER, Sternberg M et al (2007) Prevalence of HPV infection among females in the United States. Jama 297:813–819. doi:10.1001/jama.297.8.813
Schiffman MH, Hildesheim A (2006) Cervical cancer In: Schottenfeld D, Fraumeni J, Editorsin JF (eds) Cancer epidemiology and prevention, 3rd edn. Oxford University Press, New York, pp 1044–1067
Castellsague X, Munoz N (2003) Chapter 3: cofactors in human papillomavirus carcinogenesis—role of parity, oral contraceptives, and tobacco smoking. J Natl Cancer Inst Monogr, 31:20–28
Cancer Prevention and Early Detection Facts & Figures (2008) American Cancer Society, Inc, Atlanta, GA
Devesa SS, Diamond EL (1980) Association of breast cancer and cervical cancer incidence with income and education among whites and blacks. J Natl Cancer Inst 65:515–528
Khan MJ, Partridge EE, Wang SS, Schiffman M (2005) Socioeconomic status and the risk of cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology. Cancer 104:61–70. doi:10.1002/cncr.21129
National Center for Health Statistics (2006) Chartbook on trends in the health of Americans. Centers for Disease Control and Prevention, Hyattsville, MD
Watson M, Sariaiya M, Benard V et al (2008) Burden of cervical cancer in the United States, 1998–2003. Cancer 113(10 Suppl):2855–2864. doi:10.1002/cncr.23756
Espey DK, Wu XC, Swan J et al (2007) Annual report to the nation on the status of cancer, 1975–2004, featuring cancer in American Indians and Alaska Natives. Cancer 110:2119–2152. doi:10.1002/cncr.23044
Zeig-Owens R, Knowlton R, Gershman ST, Howe HL (2007) CINA highlights of cancer incidence and mortality in the United States and Canada, 2000–2004. North American Association of Central Cancer Registries, Inc, Springfield, IL
NAACCR, The North American Association of Central Cancer Registries (NAACCR); www.naaccr.org. 2008: Springfield, IL
SEER*Stat. Verison 6.3.6 (2007) National Cancer Institute, Bethesda, ML
Tiwari RC, Clegg LX, Zou Z (2006) Efficient interval estimation for age-adjusted cancer rates. Stat Methods Med Res 15:547–569. doi:10.1177/0962280206070621
Swan J, Breen N, Coates RJ, Rimer BK, Lee NC (2003) Progress in cancer screening practices in the United States: results from the 2000 National Health Interview Survey. Cancer 97:1528–1540. doi:10.1002/cncr.11208
Screening for cervical cancer: recommendations and rationale (2003) U.S. Preventive Services Task Force (January 2003). http://www.ahrq.gov/clinic/3rduspstf/carvicalcan/cervcanrr.htm. Cited 26 Feb 2008
Krane JF, Granter SR, Trask CE, Hogan CL, Lee KR (2001) Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases. Cancer 93:8–15. doi:10.1002/1097-0142(20010225)93:1<8::AID-CNCR9001>3.0.CO;2-K
Renshaw AA, Mody DR, Lozano RL et al (2004) Detection of adenocarcinoma in situ of the cervix in Papanicolaou tests: comparison of diagnostic accuracy with other high-grade lesions. Arch Pathol Lab Med 128:153–157
Singh GK, Miller BA, Hankey BF, Edwards BK (2004) Persistent area socioeconomic disparities in U.S. incidence of cervical cancer, mortality, stage, and survival, 1975–2000. Cancer 101:1051–1057. doi:10.1002/cncr.20467
Henson RM, Wyatt SW, Lee NC (1996) The National Breast and Cervical Cancer Early Detection Program: a comprehensive public health response to two major health issues for women. J Public Health Manag Pract 2:36–47
Benard VB, Eheman CR, Lawson HW et al (2004) Cervical screening in the National Breast and Cervical Cancer Early Detection Program, 1995–2001. Obstet Gynecol 103:564–571
Paskett ED, Tatum C, Rushing J et al (2004) Racial differences in knowledge, attitudes, and cancer screening practices among a triracial rural population. Cancer 101:2650–2659. doi:10.1002/cncr.20671
Vanslyke JG, Baum J, Plaza V et al (2008) HPV and cervical cancer testing and prevention: knowledge, beliefs, and attitudes among Hispanic women. Qual Health Res 18:584–596. doi:10.1177/1049732308315734
Gomez SL, Glaser SL (2006) Misclassification of race/ethnicity in a population-based cancer registry (United States). Cancer Causes Control 17:771–781. doi:10.1007/s10552-006-0013-y
Gomez SL, Kelsey JL, Glaser SL, Lee MM, Sidney S (2005) Inconsistencies between self-reported ethnicity and ethnicity recorded in a health maintenance organization. Ann Epidemiol 15:71–79. doi:10.1016/j.annepidem.2004.03.002
Stewart SL, Swallen KC, Glaser SL, Horn-Ross PL, West DW (1999) Comparison of methods for classifying Hispanic ethnicity in a population-based cancer registry. Am J Epidemiol 149:1063–1071
Swallen KC, West DW, Stewart SL, Glaser SL, Horn-Ross PL (1997) Predictors of misclassification of Hispanic ethnicity in a population-based cancer registry. Ann Epidemiol 7:200–206. doi:10.1016/S1047-2797(96)00154-8
Lepine LA, Hillis SD, Marchbanks PA et al (1997) Hysterectomy surveillance—United States, 1980–1993. MMWR CDC Surveill Summ 46:1–15
NAACCR (2007) Cancer in North America (CINA) deluxe 1995–2004 database. The North American Association of Central Cancer Registries (NAACCR), Springfield, IL. www.naaccr.org
Acknowledgments
This work was supported in part through a research grant from the North American Association of Central Cancer Registries (NAACCR) Program to JSB-S.
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Barnholtz-Sloan, J., Patel, N., Rollison, D. et al. Incidence trends of invasive cervical cancer in the United States by combined race and ethnicity. Cancer Causes Control 20, 1129–1138 (2009). https://doi.org/10.1007/s10552-009-9317-z
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DOI: https://doi.org/10.1007/s10552-009-9317-z