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RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects

  • Epidemiology
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Abstract

Several studies have investigated the associations between RAD51 G135C polymorphism and the susceptibility to breast cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 17 case control studies, including 12,153 cases and 10,245 controls, were selected. Overall, significant decreased risk was found for the additive model (OR = 0.995, 95% CI = 0.991–0.998) and dominant model (OR = 0.994, 95% CI = 0.991–0.998). In the subgroup analysis by ethnicity, statistically significantly decreased risk was found in Asians (additive model: OR = 0.977, 95% CI = 0.954–1.000 and dominant model: OR = 0.981, 95% CI = 0.963–1.000). In conclusion, this meta-analysis suggests that the RAD51 G135C polymorphism is a low-penetrant risk factor for developing breast cancer.

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Acknowledgments

The project was supported by National Natural Science Foundation of China (No.30671146).

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Authors and Affiliations

  1. Laboratory of Medical Genetics, Harbin Medical University, Baojian Road 157, Nangang District, Harbin, 150081, China

    Haiming Sun, Jing Bai, Feng Chen, Yan Jin, Yang Yu & Songbin Fu

  2. Key Laboratory of Medical Genetics (Harbin Medical University), Heilongjiang Higher Education Institutions, Harbin, China

    Yan Jin

  3. Department of Histology and Embryology, Harbin Medical University, Harbin, 150081, China

    Lianhong Jin

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  1. Haiming Sun
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Correspondence to Songbin Fu.

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Sun, H., Bai, J., Chen, F. et al. RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects. Breast Cancer Res Treat 125, 157–161 (2011). https://doi.org/10.1007/s10549-010-0922-z

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  • DOI: https://doi.org/10.1007/s10549-010-0922-z

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