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Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients

  • Epidemiology
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Abstract

Background Data on distant disease-free interval (DDFI) and the localization of the first distant metastasis (DM) in BRCA1- and BRCA2-associated breast cancer (BC) patients are as yet scarcely available. Patients and methods We identified 57 BRCA1-associated and 31 BRCA2-associated BC patients, diagnosed between 1980 and 2001, and developing DM disease before 2004, July 1. DDFI, the site(s) of first DM and post-relapse survival of these patients were compared with those of 192 sporadic BC patients. Results As compared to sporadic patients, BRCA1 patients developed less often bone DM (30% vs. 51%; P = 0.005), but tended to develop more often lung DM (26% vs. 16%; P = 0.07), and DM at multiple sites (44% vs. 32%; P = 0.11). In BRCA2-associated compared to sporadic patients, first DM more commonly occurred in lymph nodes (23% vs. 7%; P = 0.007) and at multiple sites (48% vs. 32%; P = 0.08). Adjuvant systemic therapy appeared to be most effective in BRCA2 mutation carriers. Post-relapse survival was worse for BRCA1- and better for BRCA2-associated patients as compared to sporadic patients, but differences disappeared after adjustment for ER-status, site of first DM and DDFI. Conclusion The site of first DM is different between BRCA1- and BRCA2-associated and sporadic BC patients. Differences in post-relapse survival could be explained by differences in site of first DM, in ER-status and in DDFI. Treatment efficacy may differ dependent on genetic status.

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Fig. 1

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Abbreviations

BC:

Breast cancer

DDFI:

Distant disease-free interval

DM:

Distant metastasis

ER:

Estrogen receptor

PgR:

Progesterone receptor

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Acknowledgements

The study was supported by a grant from the Dutch Cancer Society (DDHK 2004-3124) and Cancer Genomics Center. We thank Ellen Crepin, Jannet Blom and Elisabeth Huijskens for the collection of data.

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Author notes

  1. Hanne Meijers-Heijboer

    Present address: Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands

Authors and Affiliations

  1. Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands

    Mieke Kriege, Caroline Seynaeve, Cecile T. M. Brekelmans & Jan G. M. Klijn

  2. Family Cancer Clinic, Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands

    Hanne Meijers-Heijboer, J. Margriet Collee & Ans van den Ouweland

  3. Family Cancer Clinic, Department of Surgery, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    Marian B. E. Menke-Pluymers, Carina C. M. Bartels, Madeleine M. A. Tilanus-Linthorst & Bert van Geel

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Correspondence to Mieke Kriege.

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Kriege, M., Seynaeve, C., Meijers-Heijboer, H. et al. Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. Breast Cancer Res Treat 111, 303–311 (2008). https://doi.org/10.1007/s10549-007-9781-7

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  • DOI: https://doi.org/10.1007/s10549-007-9781-7

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