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Role of cyclin D1 in ErbB2-positive breast cancer and tamoxifen resistance

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Abstract

Cyclin D1 plays an important role in the regulation of the G1 phase in the cell cycle. In mammary epithelial cells the expression of cyclin D1 is regulated through the oestrogen receptor and via ErbB2 signalling. Here we investigated the prognostic significance of cyclin D1 among 230 breast cancer patients randomised for tamoxifen, CMF chemotherapy and radiotherapy. The importance of combined cyclin D1 and ErbB2 overexpression was also analysed. Immunohistochemical analysis of the cyclin D1 expression resulted in 69 (29.8%) weakly positive, 107 (46.5%) moderately positive and 54 (23.7%) strongly positive cases. The prognostic importance of ErbB2 was significantly greater for patients whose tumours overexpressed cyclin D1 than for other patients (p = 0.026). In the former group, ErbB2 overexpression was strongly associated with increased risk of recurrence (RR = 4.7; 95% CI, 2.1–10.4) and breast cancer death (RR = 5.4; 95% CI, 2.3–12.6). This result is in accordance with experimental studies demonstrating a link between cyclin D1 and ErbB2 in oncogenesis. Among oestrogen receptor positive patients, those with moderate cyclin D1 expression significantly did benefit from tamoxifen treatment (RR = 0.42; 95% CI, 0.21–0.82) whereas those with weak or strong expression did not. Therefore cyclin D1 might be a predictive marker for tamoxifen resistance.

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Authors and Affiliations

  1. Department of Biomedicine and Surgery, Division of Oncology, University Hospital, SE-581 85, Linköping, Sweden

    Marie Ahnström, Bo Nordenskjöld & Olle Stål

  2. Department of Oncology, Huddinge University Hospital, Stockholm

    Lars Erik Rutqvist

  3. Department of Cytology, Karolinska Hospital, Stockholm, Sweden

    Lambert Skoog

  4. Department of Biomedicine and Surgery, Division of Oncology, Faculty of Health Sciences, Linköping University, Linköping

    Marie Ahnström

Authors
  1. Marie Ahnström
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  2. Bo Nordenskjöld
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  3. Lars Erik Rutqvist
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  4. Lambert Skoog
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  5. Olle Stål
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Correspondence to Marie Ahnström.

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Ahnström, M., Nordenskjöld, B., Rutqvist, L.E. et al. Role of cyclin D1 in ErbB2-positive breast cancer and tamoxifen resistance. Breast Cancer Res Treat 91, 145–151 (2005). https://doi.org/10.1007/s10549-004-6457-4

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  • DOI: https://doi.org/10.1007/s10549-004-6457-4

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