Summary
There is increasing evidence that oral clodronate has important clinical benefits in early breast cancer. Longer-term follow-up data from two out of three randomized studies have shown that adjuvant clodronate improves survival. This article outlines the results of these studies and discusses the potential role for other bisphosphonates, such as ibandronate and zoledronic acid, in the adjuvant treatment of breast cancer.
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References
RL Theriault GN Hortobagyi (1992) ArticleTitleBone metastasis in breast cancer Anticancer Drugs 3 455–462 Occurrence Handle1450438 Occurrence Handle1:STN:280:ByyD1c7ot10%3D
RE Coleman (1997) ArticleTitleSkeletal complications of malignancy Cancer 80 IssueIDSuppl 8 1588–1594 Occurrence Handle9362426 Occurrence Handle1:STN:280:DyaK1c%2Fis1Onuw%3D%3D
Pavlakis N, Stockler M (2002) Bisphosphonates for breast cancer. Cochrane Database Syst Rev 1: CD003474
JR Ross Y Saunders PM Edmonds S Patel KE Broadley SR Johnston (2003) ArticleTitleSystematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer BMJ 30 469
JR Gralow (2002) ArticleTitleBisphosphonates as adjuvant treatment for breast cancer BMJ 325 1051–1052 Occurrence Handle12424151
Diel IJ, Solomayer EF: Bisphosphonates in the reduction of metastases in breast cancer – results of the extended follow-up of the first study population. Proc Am Soc Clin Oncol 19: (abs 314), 2000
Jaschke A, Bastert G, Solomayer EF, Costa S, Schuetz F, Diel IJ: Adjuvant clodronate treatment improves the overall survival of primary breast cancer patients with micrometastases to bone marrow – a longtime follow-up. Proc Am Soc Clin Oncol 23: (abs 529), 2004
T Powles S Paterson J Kanis E McCloskey S Ashley A Tidy K Rosenqvist I Smith L Ottestad S Legault M Pajunen A Nevantaus E Mannisto A Suovuori S Atula J Nevalainen L Pylkkanen (2002) ArticleTitleRandomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer J Clin Oncol 20 3219–3224 Occurrence Handle12149294
Powles T, Paterson A, McCloskey E, Kurkilahti M, Kanis J: Oral clodronate for adjuvant treatment of operable breast cancer: results of a randomized, double-blind, placebo-controlled multicenter trial. Proc Am Soc Clin Oncol 23: (abs 528), 2004
T Saarto C Blomqvist P Virkkunen I Elomaa (2001) ArticleTitleAdjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial J Clin Oncol 19 10–17 Occurrence Handle11134190 Occurrence Handle1:STN:280:DC%2BD38%2Fls1SqsQ%3D%3D
Saarto T, Vehmanen L, Blomqvist C, Elomaa I: Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment. Proc Am Soc Clin Oncol 23: (abs 527), 2004
Kokufu I, Kohno N, Takao S, Yamamoto M, Miyashita M, Kohno S, Kimura F: Adjuvant pamidronate therapy prevents. Proc Am Soc Clin Oncol 23: (abs 530), 2004
AH Paterson TJ Powles JA Kanis E McCloskey J Hanson S Ashley (1993) ArticleTitleDouble-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer J Clin Oncol 11 59–65 Occurrence Handle8418243 Occurrence Handle1:STN:280:ByyC3MrnvVY%3D
AG Robertson NS Reed SH Ralston (1995) ArticleTitleEffect of oral clodronate on metastatic bone pain: a double-blind, placebo-controlled study J Clin Oncol 13 2427–2430 Occurrence Handle7666103 Occurrence Handle1:STN:280:ByqA1MrltVU%3D
G Pluijm Particlevan der H Vloedgraven E Beek Particlevan L Wee-Pals Particlevan der C Lowik S Papapoulos (1996) ArticleTitleBisphosphonates inhibit adhesion of breast cancer cells to bone matrices in vitro J Clin Invest 98 698–705 Occurrence Handle10.1172/JCI118841 Occurrence Handle8698861
S Magnetto S Boissier PD Delmas P Clezardin (1999) ArticleTitleAdditive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone Int J Cancer 83 263–269 Occurrence Handle10471537 Occurrence Handle1:STN:280:DyaK1MvgtVKrtg%3D%3D
S Boissier M Ferreras O Peyruchaud S Magnetto FH Ebetino M Colombel P Delmas JM Delaisse P Clezardin (2000) ArticleTitleBisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases Cancer Res 60 2949–2954 Occurrence Handle10850442 Occurrence Handle1:STN:280:DC%2BD3czgs1Kitw%3D%3D
O Fromigue L Lagneaux J-J Body (2000) ArticleTitleBisphosphonates induce breast cancer cell death in vitro J Bone Miner Res 15 2211–2221 Occurrence Handle11092402 Occurrence Handle1:STN:280:DC%2BD3MzgsFKmuw%3D%3D
P Fournier S Boissier S Filleur J Guglielmi F Cabon M Colombel P Clezardin (2002) ArticleTitleBisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats Cancer Res 62 6538–6544 Occurrence Handle12438248
D Tripathy M Lichinitzer A Lazarev SA MacLachlan J Apffelstaedt M Budde B Bergstrom (2004) ArticleTitleMF 4434 Study Group: Oral ibandronate for the treatment of metastatic bone disease in breast cancer: efficacy and safety results from a randomized, double-blind, placebo-controlled trial Ann Oncol 15 743–750 Occurrence Handle15111341 Occurrence Handle1:STN:280:DC%2BD2c3htFymsw%3D%3D
JJ Body IJ Diel M Lichinitzer A Lazarev M Pecherstorfer R Bell D Tripathy B Bergstrom (2004) ArticleTitleOral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies Br J Cancer 90 1133–1137 Occurrence Handle15026791 Occurrence Handle1:STN:280:DC%2BD2c7jtlCiuw%3D%3D
R Bell IJ Diel JJ Body B Bergström (2004) ArticleTitleRenal safety of ibandronate in patients with bone metastases from breast cancer: phase III trial results Eur J Cancer Suppl 2 132
M Borner W Scheithauer C Twelves J Maroun H Wilke (2001) ArticleTitleAnswering patients’ needs: oral alternatives to intravenous therapy Oncologist 6 IssueIDSuppl 4 12–16 Occurrence Handle11585969
M Gnant H Hausmaninger H Samonigg B Mlineritsch S Taucher G Luschin-Ebengreuth R Jakesz (2002) ArticleTitleChanges in bone mineral density caused by anastrazole or tamoxifen in combination with goserelin (+/− zoledronate) as adjuvant treatment for hormone receptor positive premenopausal breast cancer: results of a randomised multicenter trial Breast Cancer Res Treat 76 IssueIDSuppl 1 S31
R Theriault R Jakesz M Gnant J Gralow (2004) ArticleTitleThe evolving role of bisphosphonates for the prevention of cancer treatment-induced bone loss in patients with breast cancer Bone 34 IssueIDSuppl 1 S90
R Coleman J Gralow R Bell A Lipton (2004) ArticleTitleZoledronic acid is being investigated for the prevention of bone metastases in patients with early stage breast cancer Bone 34 IssueIDSuppl 1 S85
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Clemons, M., Verma, S. Should oral bisphosphonates be standard of care in women with early breast cancer?. Breast Cancer Res Treat 90, 315–318 (2005). https://doi.org/10.1007/s10549-004-4259-3
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DOI: https://doi.org/10.1007/s10549-004-4259-3