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Feasibility study on Ti-15Mo-7Cu with low elastic modulus and high antibacterial property

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Abstract

Titanium and titanium alloy with low density, high specific strength, good biological, excellent mechanical compatibility and easy to process have been widely used in the medical materials, but their application in orthopedics and dentistry often face bacterial infection, corrosion failure and stress shielding. In this paper, Ti–15Mo–7Cu (TM–7Cu) alloy was prepared by high vacuum non-consumable electric arc melting furnace and then treated by solution and aging treatment. The microstructure, mechanical properties, antibacterial properties and cytocompatibility were studied by X-ray diffraction, microhardness tester, electrochemical working station, antibacterial test and Live/Dead staining technology. The results have shown that the heat treatment significantly influenced the phase transformation, the precipitation of Ti2Cu phase, the elastic modulus and the antibacterial ability. With the extension of the aging time, the elastic modulus slightly increased and the antibacterial rate obviously increased. TM–7Cu alloy with a low elastic modulus of 83GPa and a high antibacterial rate of > 93% was obtained. TM–7Cu alloy showed no cytotoxicity to MC3T3. It was suggested that TM–7Cu might be a highly competitive medical material.

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Acknowledgements

This study was supported by the National Science Foundation of China (No.31971253), Joint plan of key R & D projects in Liaoning Province (2020JH2/10300157) and Shenyang Science and technology plan in 2020 (20-205-4-023).

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Authors and Affiliations

  1. Key Laboratory for Anisotropy and Texture of Materials, Education Ministry of China, School of Materials Science and Engineering, Northeastern University, Shenyang, 110819, China

    Shenshen Cui, Anqi Shi, Lei Yang, Gaowu Qin & Erlin Zhang

  2. Northern Theater General Hospital, Shenyang, 110016, China

    Yanchun Xie, Hailong Yu & Yongcun Wei

  3. Research Center for Metallic Wires, Northeastern University, Shenyang, 110819, China

    Gaowu Qin & Erlin Zhang

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  1. Shenshen Cui
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Correspondence to Erlin Zhang.

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Cui, S., Shi, A., Xie, Y. et al. Feasibility study on Ti-15Mo-7Cu with low elastic modulus and high antibacterial property. Biometals 35, 1225–1241 (2022). https://doi.org/10.1007/s10534-022-00438-w

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