Abstract
Some studies have demonstrated the participation of leptin in magnesium metabolism. On the other hand, there is evidence of the role of magnesium in the leptin intracellular signaling pathway. Therefore, the aim of this study was to investigate the existence of a relationship between serum leptin concentrations and magnesium biomarkers in women with obesity. Case–control study involving 108 women aged between 20 and 50 years, divided into two groups: obese (n = 52) and control (n = 56). Body weight, height and waist circumference, body mass index, dietary magnesium intake, magnesium biomarkers and serum leptin concentrations were measured. Serum leptin concentrations showed a statistically significant difference between groups (p < 0.001). Mean values of magnesium intake were lower than intake recommended, and with no statistically significant difference between two groups (p > 0.05). Women with obesity had lower plasma and erythrocyte magnesium concentrations than control group did (p < 0.001). Magnesium concentrations found in the urine of women with obesity were higher than the control group was, with a statistically significant difference (p < 0.001). There was a correlation between serum leptin and magnesium biomarkers (p < 0.001). Women with obesity show an inadequate magnesium nutritional status characterized by low plasma and erythrocyte concentrations and high concentrations in urine, and they also have high serum leptin concentrations. Thus, it was possible to observe a correlation between hyperleptinemia and magnesium biomarkers, requiring further studies to determine whether the dysfunction of this hormone can influence the compartmentalization of the mineral in obese organisms.
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Data supporting the results of this study will be de-identified upon request to the corresponding author [DNM]. The data are not publicly available due to containing information such as socioeconomic data, name, email, telephone and address of the participants. Study data will be available upon request.
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SRM and DNM conceived the ideia of study, SRSM, LRS JBSM, KJCC, ARSO, NCS and GSS collection of biological material, data tabulation and drafted the manuscript, SRSM, KJCC and DNM manuscript review, statistical analysis and construction of graphic schemes, TBP, GM, SB and GSH biochemical analyses.
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The study was approved by Research Ethics Committee of the Federal University of Piaui, protocol number 13489613.5.0000.5214, and conducted in accordance with the Declaration of Helsinki. All patients signed a consent form.
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de Sousa Melo, S.R., dos Santos, L.R., Morais, J.B.S. et al. Leptin and its relationship with magnesium biomarkers in women with obesity. Biometals 35, 689–697 (2022). https://doi.org/10.1007/s10534-022-00393-6
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DOI: https://doi.org/10.1007/s10534-022-00393-6