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Antibacterial and immunomodulatory activities of bovine lactoferrin against Escherichia coli O157:H7 infections in cattle

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Abstract

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E. coli O157:H7 infections in cattle. This paper provides an overview of latest research data on eradicating enterohemorrhagic E. coli O157:H7 in ruminants by use of bovine lactoferrin administration. The article provides insights into the anti-microbial and immunomodulatory activities of bovine lactoferrin against E. coli O157:H7 infections in cattle.

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Acknowledgements

The research was funded by the Belgian Federal Public Service of Health, Food Chain Safety and Environment (RF10/6233). The Research Foundation Flanders (FWO Vlaanderen) is also acknowledged for financial support.

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  1. Evelien Kieckens and Joanna Rybarczyk have contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium

    Evelien Kieckens, Joanna Rybarczyk & Daisy Vanrompay

  2. Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium

    Eric Cox

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  1. Evelien Kieckens
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  2. Joanna Rybarczyk
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Correspondence to Daisy Vanrompay.

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Daisy Vanrompay and Eric Cox share senior authorship.

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Kieckens, E., Rybarczyk, J., Cox, E. et al. Antibacterial and immunomodulatory activities of bovine lactoferrin against Escherichia coli O157:H7 infections in cattle. Biometals 31, 321–330 (2018). https://doi.org/10.1007/s10534-018-0082-x

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