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Cadmium Toxicity in Plants: Is There any Analogy to its Carcinogenic Effect in Mammalian Cells?

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Abstract

Cadmium is a heavy metal, which is classified as a human carcinogen and is known to be toxic to plants. However, plants do not respond to this metal by massive cell proliferation. In this review the various aspects of cadmium toxicity in plants are compared to related processes in mammalian cells. The following issues are discussed: cellular uptake of Cd ions, their intracellular transport, the effects on cellular signaling, nucleic acids and proteins, modification of gene expression, cell cycle control and apoptosis. Reviewed data suggest that such features as: ability to remove the oxidized proteins, slightly different regulation of cell cycle genes, specific pattern of apoptosis, makes plants resistant to Cd2+-induced uncontrolled cell proliferation.

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References

  • S Araki M Ito T Soyano R Nishihama Y Machida (2004) ArticleTitleMitotic cyclins stimulate the activity of c-Myb-like factors for transactivation of G2/M phase-specific genes in tobacco J Biol Chem 279 32979–32988 Occurrence Handle15175336 Occurrence Handle1:CAS:528:DC%2BD2cXmtVChu7s%3D

    PubMed  CAS  Google Scholar 

  • G Banfalvi N Littlefield B Hass M Mikahailova I Csuka E Szepessy MW Chou (2000) ArticleTitleEffect of cadmium on the relationship between replicative and repair DNA synthesis in synchronized CHO cells Eur J Biochem 267 6580–6585 Occurrence Handle11054109 Occurrence Handle1:CAS:528:DC%2BD3cXotF2qtrw%3D Occurrence Handle10.1046/j.1432-1327.2000.01751.x

    Article  PubMed  CAS  Google Scholar 

  • D Bartels R Sunkar (2005) ArticleTitleDrough and salt tolerance in plants Crit Rev Plant Sci 24 23–58 Occurrence Handle1:CAS:528:DC%2BD2MXis12ns7c%3D

    CAS  Google Scholar 

  • BS Berlett ER Stadtman (1997) ArticleTitleProtein oxidation in aging, diseases, and oxidative stress J Biol Chem 272 20313–20316 Occurrence Handle9252331 Occurrence Handle1:CAS:528:DyaK2sXlsFKhsbw%3D Occurrence Handle10.1074/jbc.272.33.20313

    Article  PubMed  CAS  Google Scholar 

  • C Bernard N Roosens P Czernic N Lebrun N Verbruggen (2004) ArticleTitleA novel CPx-ATPase from the cadmium hyperacumulator Thlaspi caerulescens FEBS Lett 569 140–148 Occurrence Handle15225623 Occurrence Handle1:CAS:528:DC%2BD2cXlt1amtLs%3D Occurrence Handle10.1016/j.febslet.2004.05.036

    Article  PubMed  CAS  Google Scholar 

  • D Beyersmann S Hechtenberg (1997) ArticleTitleCadmium, gene regulation and cellular signaling in mamaliian cells Toxicol Appl Pharmacol 144 247–261 Occurrence Handle9194408 Occurrence Handle1:CAS:528:DyaK2sXjsl2jtLs%3D Occurrence Handle10.1006/taap.1997.8125

    Article  PubMed  CAS  Google Scholar 

  • J Boonstra JA Post (2004) ArticleTitleMolecular events associated with reactive oxygen species and cell cycle progression in mammalian cells Gene 337 1–13 Occurrence Handle15276197 Occurrence Handle1:CAS:528:DC%2BD2cXlvFaqsLk%3D Occurrence Handle10.1016/j.gene.2004.04.032

    Article  PubMed  CAS  Google Scholar 

  • L Bovet T Eggmann M Meylan-Bettex J Polier P Kammer E Marin U Feller E Martinoia (2003) ArticleTitleTranscript levels of AtMRPs after cadmium treatment: induction of AtMRP3 Plant Cell Environ 26 371–381 Occurrence Handle1:CAS:528:DC%2BD3sXjtVylt7c%3D Occurrence Handle10.1046/j.1365-3040.2003.00968.x

    Article  CAS  Google Scholar 

  • M Burzyński M Migocka G Kłobus (2005) ArticleTitleCu and Cd transport in cucumber (Cucumis sativus L.) root plasma membranes Plant Sci 168 1609–1614

    Google Scholar 

  • S Clemens (2001) ArticleTitleMolecular mechanisms of plant metal tolerance and homeostasis Planta 212 475–486 Occurrence Handle11525504 Occurrence Handle1:CAS:528:DC%2BD3MXhs1Cgtr8%3D Occurrence Handle10.1007/s004250000458

    Article  PubMed  CAS  Google Scholar 

  • CS Cobbett (2003) ArticleTitleMetals and Plants. Model systems and hyperaccumulator species New Phytol 159 289–293

    Google Scholar 

  • P Das S Samantaray GR Rout (1997) ArticleTitleStudies on cadmium toxicity in plants: A review Environ Pollut 98 29–36 Occurrence Handle15093342 Occurrence Handle1:CAS:528:DyaK1cXht12isLo%3D Occurrence Handle10.1016/S0269-7491(97)00110-3

    Article  PubMed  CAS  Google Scholar 

  • J Doonan T Hunt (1996) ArticleTitleWhy don’t plants get cancer? Nature 380 481–482 Occurrence Handle8606760 Occurrence Handle1:CAS:528:DyaK28Xit1Omu70%3D Occurrence Handle10.1038/380481a0

    Article  PubMed  CAS  Google Scholar 

  • M Filipic T Hei (2004) ArticleTitleMutagenicity of cadmium in mammalian cells: implication of oxidative DNA damage Mutat Res 546 81–91 Occurrence Handle14757196 Occurrence Handle1:CAS:528:DC%2BD2cXnvVeitQ%3D%3D

    PubMed  CAS  Google Scholar 

  • M Fojtová A Kovarik (2000) ArticleTitleGenotoxic effect of cadmium is associated with apoptic changes in tobacco cells Plant Cell Environ 23 531–537

    Google Scholar 

  • M Fojtová J Fulneckova J Fajkus A Kovarik (2002) ArticleTitleRecovery of tobacco cells from cadmium stress is accompanied by DNA repair and increased telomerase activity J Exp Bot 378 2151–2158

    Google Scholar 

  • T Ghelis O Dellis E Jeannette F Bardat E Miginiac B Sott (2000) ArticleTitleAbscisic acid plasmalemma perception triggers a calcium influx essential for RAB18 gene expression in Arabidopsis thaliana suspension cells FEBS Lett 483 67–70 Occurrence Handle11033358 Occurrence Handle1:CAS:528:DC%2BD3cXntF2qtbk%3D Occurrence Handle10.1016/S0014-5793(00)02088-3

    Article  PubMed  CAS  Google Scholar 

  • T Gichner Z Patkova J Szkova K Domnerova (2004) ArticleTitleCadmim induces DNA damage in tobacco roots, but no DNA damage, somatic mutations or homologous recombination in tobacco leaves Mutat Res 559 49–57 Occurrence Handle15066573 Occurrence Handle1:CAS:528:DC%2BD2cXisl2rsbc%3D

    PubMed  CAS  Google Scholar 

  • JL Hall (2002) ArticleTitleCellular mechanisms for heavy metal detoxification and tolerance J Exp Bot 53 1–11 Occurrence Handle11741035 Occurrence Handle1:CAS:528:DC%2BD3MXptlKgtLw%3D Occurrence Handle10.1093/jexbot/53.366.1

    Article  PubMed  CAS  Google Scholar 

  • JL Hall LE Williams (2003) ArticleTitleTransition metal transporters in plants J Exp Bot 54 2601–2613 Occurrence Handle14585824 Occurrence Handle1:CAS:528:DC%2BD3sXpvVemtbk%3D Occurrence Handle10.1093/jxb/erg303

    Article  PubMed  CAS  Google Scholar 

  • A Hartwig (2001) ArticleTitleZink finger proteins as potential targets for toxic metal ions: differential effects on structure and function Antioxid Redox Signal 3 625–634 Occurrence Handle11554449 Occurrence Handle1:CAS:528:DC%2BD3MXmtlCrtrg%3D Occurrence Handle10.1089/15230860152542970

    Article  PubMed  CAS  Google Scholar 

  • H Hirt G Casari A Barta (1989) ArticleTitleCadmium enhanced gene expression in suspension-culture cells of tobacco Planta 179 414–420 Occurrence Handle1:CAS:528:DyaL1MXmt12itbc%3D Occurrence Handle10.1007/BF00391089

    Article  CAS  Google Scholar 

  • Z Hossain F Huq (2002) ArticleTitleStudies on the interaction between Cd2+ ions and DNA J Inorg Biochem 90 85–96 Occurrence Handle12031800 Occurrence Handle1:CAS:528:DC%2BD38XjvVaqsb4%3D

    PubMed  CAS  Google Scholar 

  • D Inze (2005) ArticleTitleGreen light for the cell cycle EMBO 24 657–662 Occurrence Handle1:CAS:528:DC%2BD2MXhsFWlsbk%3D

    CAS  Google Scholar 

  • M Ito S Araki S Matsunaga T Itoh R Nishihama Y Machida JH Doonan A Watanabe (2001) ArticleTitleG2/M-Phase-specific transcription during the plant cell cycle is mediated by c-Myb-like transcription factors Plant Cell 13 1891–1905 Occurrence Handle11487700 Occurrence Handle1:CAS:528:DC%2BD3MXmsFKiu7k%3D Occurrence Handle10.1105/tpc.13.8.1891

    Article  PubMed  CAS  Google Scholar 

  • YH Jin AB Clark RJC Slebos H Al-Refai JA Taylor TA Kunkel MA Resnick DA Gordenin (2003) ArticleTitleCadmium is a mutagen that acts by inhibiting mismatch repair Nature Genet 34 326–329 Occurrence Handle12796780 Occurrence Handle1:CAS:528:DC%2BD3sXkvFSrsrg%3D Occurrence Handle10.1038/ng1172

    Article  PubMed  CAS  Google Scholar 

  • E Johansson O Olsson T Nyström (2004) ArticleTitleProgression and specifity of protein oxidation in the life cycle of Arabidopsis thaliana J Biol Chem 279 22204–22206 Occurrence Handle15070894 Occurrence Handle1:CAS:528:DC%2BD2cXjvF2rsLc%3D Occurrence Handle10.1074/jbc.M402652200

    Article  PubMed  CAS  Google Scholar 

  • C Jonak H Nakagami H Hirt (2004) ArticleTitleHeavy metal stress. Activation of distinct mitogen-activated protein kinase pathways by copper and cadmium Plant Physiol 136 3276–3283 Occurrence Handle15448198 Occurrence Handle1:CAS:528:DC%2BD2cXovVymsL0%3D Occurrence Handle10.1104/pp.104.045724

    Article  PubMed  CAS  Google Scholar 

  • P Joseph YX Lei TM Ong (2004) ArticleTitleUp-regulation of expression of translational factors – a novel molecular mechanism for cadmium carcinogenesis Mol Cell Biol 255 1–2

    Google Scholar 

  • WS Klug MR Cummings ChA Spencer (2005) Cell cycle regulation and cancer WS Klug MR Cummings (Eds) Concepts of Genetics Pearson Educational International – Prentice Hall Saddler River, NY 434–456

    Google Scholar 

  • G Koppen L Verschaeve (1996) ArticleTitleThe alkaline comet test on plant cell: a new genotoxicity test for DNA strand breaks in Vicia faba root cells Mutat Res 360 193–200 Occurrence Handle8692219 Occurrence Handle1:CAS:528:DyaK28XktVygsL8%3D

    PubMed  CAS  Google Scholar 

  • YO Korshunova D Eide WG Clark ML Guerinot HB Pakrasi (1999) ArticleTitleThe IRT1 protein from Arabidopsis thaliana is a metal transporter with a broad substrate range Plant Mol Biol 40 37–44 Occurrence Handle10394943 Occurrence Handle1:CAS:528:DyaK1MXksF2hsrY%3D Occurrence Handle10.1023/A:1026438615520

    Article  PubMed  CAS  Google Scholar 

  • I Kovalchuk V Titov B Hohn O Kovalchuk (2005) ArticleTitleTranscriptome profiling reveals similarities and differences in plant responses to cadmium and lead Mutat Res 570 149–161 Occurrence Handle15708574 Occurrence Handle1:CAS:528:DC%2BD2MXhtlSlsro%3D

    PubMed  CAS  Google Scholar 

  • Y Kovtun WL Chiu G Tena J Sheen (2000) ArticleTitleFunctional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants Proc Natl Acad Sci USA 97 2940–2945 Occurrence Handle10717008 Occurrence Handle1:CAS:528:DC%2BD3cXitVaht70%3D Occurrence Handle10.1073/pnas.97.6.2940

    Article  PubMed  CAS  Google Scholar 

  • Ch Laloi K Apel A Danon (2004) ArticleTitleRective oxygene signalling: the latest news Curr Opin Plant Biol 7 323–328 Occurrence Handle15134754 Occurrence Handle1:CAS:528:DC%2BD2cXjvVamsLg%3D Occurrence Handle10.1016/j.pbi.2004.03.005

    Article  PubMed  CAS  Google Scholar 

  • TW Lane MA Saito GN George IJ Pickering RC Prince FMM Morell (2005) ArticleTitleA cadmium enzyme from marine diatom Nature 435 42 Occurrence Handle15875011 Occurrence Handle1:CAS:528:DC%2BD2MXjvVKntLY%3D Occurrence Handle10.1038/435042a

    Article  PubMed  CAS  Google Scholar 

  • S Lindberg T Landberg M Greger (2004) ArticleTitleA new method to detect cadmium uptake in protoplasts Planta 219 526–532 Occurrence Handle15069560 Occurrence Handle1:CAS:528:DC%2BD2cXlsVCkurY%3D Occurrence Handle10.1007/s00425-004-1256-z

    Article  PubMed  CAS  Google Scholar 

  • R Mahalingam N Fedoroff (2003) ArticleTitleStress response, cell death and signalling: the many faces of reactive oxygen species Physiol Plant 119 56–68 Occurrence Handle1:CAS:528:DC%2BD3sXnt1Wqtr4%3D Occurrence Handle10.1034/j.1399-3054.2003.00156.x

    Article  CAS  Google Scholar 

  • CT McMurray J Tainer (2003) ArticleTitleCancer, cadmium and genome integrity Nature Genet 34 239–241 Occurrence Handle12833042 Occurrence Handle1:CAS:528:DC%2BD3sXkvFSku7g%3D Occurrence Handle10.1038/ng0703-239

    Article  PubMed  CAS  Google Scholar 

  • M Mikołajczyk OS Awotunde G Muszyńska DF Klessig G Dobrowolska (2000) ArticleTitleOsmotic stress induces rapid activation of a salicylic acid-induced protein kinase and a homolog of protein kinase ASK1 in tobacco cells Plan Cell 12 165–168

    Google Scholar 

  • RF Mills GC Krijger PJ Baccarini JL Hall LE Williams (2003) ArticleTitleFunctional expression of AtHMA4: A P1b-type ATPase of the Zn/Co/Cd/Pb subclass Plant J 35 164–176 Occurrence Handle12848823 Occurrence Handle1:CAS:528:DC%2BD3sXmvFSmu78%3D Occurrence Handle10.1046/j.1365-313X.2003.01790.x

    Article  PubMed  CAS  Google Scholar 

  • V Mironov L Velder ParticleDe M Montagu ParticleVan D Inze (1999) ArticleTitleCyclin-dependent kinases and cell division in plants – The Nexus Plant Cell 11 509–521 Occurrence Handle10213774 Occurrence Handle1:CAS:528:DyaK1MXjtFSrtbo%3D Occurrence Handle10.1105/tpc.11.4.509

    Article  PubMed  CAS  Google Scholar 

  • T Nyström (2005) ArticleTitleRole of oxidative carbonylation in protein quality control and senescence EMBO 24 1311–1317

    Google Scholar 

  • S Pelengaris M Khan (2003) ArticleTitleThe many faces of c-MYC Arch Biochem Biophys 416 129–136 Occurrence Handle12893289 Occurrence Handle1:CAS:528:DC%2BD3sXlvVCksrk%3D Occurrence Handle10.1016/S0003-9861(03)00294-7

    Article  PubMed  CAS  Google Scholar 

  • NS Pence PB Larsen SD Ebbs DL Lethman MM Lasat DF Garvin D Eide LV Kochian (2000) ArticleTitleThe molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens Proc Natl Acad Sci USA 97 4956–4960 Occurrence Handle10781104 Occurrence Handle1:CAS:528:DC%2BD3cXivFKisrk%3D Occurrence Handle10.1073/pnas.97.9.4956

    Article  PubMed  CAS  Google Scholar 

  • L Perfus-Barbeoch N Leonhardt A Vavaddeur C Forestier (2002) ArticleTitleHeavy metal toxicity: Cadmim permeates through calcium channels and disturbs the plant water status Plant J 32 539–548 Occurrence Handle12445125 Occurrence Handle1:CAS:528:DC%2BD38Xps1Kru7w%3D Occurrence Handle10.1046/j.1365-313X.2002.01442.x

    Article  PubMed  CAS  Google Scholar 

  • MD Pulido AR Parrish (2003) ArticleTitleMetal-induced apoptosis: Mechanisms Mutat Res 533 227–241 Occurrence Handle14643423 Occurrence Handle1:CAS:528:DC%2BD3sXpt1eru7s%3D

    PubMed  CAS  Google Scholar 

  • WE Rauser (1995) ArticleTitlePhytochelatines and related peptides. Structure, biosynthesis and function Plant Physiol 109 1141–1149 Occurrence Handle8539285 Occurrence Handle1:CAS:528:DyaK2MXhtVSnsb7M

    PubMed  CAS  Google Scholar 

  • J-P Reichheld T Vernoux F Lardon M Monatgu ParticleVan D Inze (1999) ArticleTitleSpecific checkpoints regulate plant cell cycle progression in response to oxidative stress Plant J 17 647–656 Occurrence Handle1:CAS:528:DyaK1MXivVSqsr0%3D Occurrence Handle10.1046/j.1365-313X.1999.00413.x

    Article  CAS  Google Scholar 

  • MC Romero-Puertas JM Palma M Gomez LA Del Rio LM Sandalio (2002) ArticleTitleCadmium cause the oxidative modification of proteins in pea plants Plant Cell Environ 25 677–686 Occurrence Handle1:CAS:528:DC%2BD38XktlertLg%3D Occurrence Handle10.1046/j.1365-3040.2002.00850.x

    Article  CAS  Google Scholar 

  • L Sanita di Toppi R Gabbrielli (1999) ArticleTitleResponse to cadmium in higher plant Environ Exp Bot 41 105–130

    Google Scholar 

  • M Sanmartin L Jaroszewski V Raikhel E Rojo (2005) ArticleTitleCaspase. Regulating death since the origin of life Plant Physiol 137 841–847 Occurrence Handle15761210 Occurrence Handle1:CAS:528:DC%2BD2MXislOrurc%3D Occurrence Handle10.1104/pp.104.058552

    Article  PubMed  CAS  Google Scholar 

  • K Shah RS Dubey (1995) ArticleTitleEffect of cadmium on RNA level as well as activity and molecular forms of ribonuclease in growing rice seedlings Plant Physiol Biochem 33 577–584 Occurrence Handle1:CAS:528:DyaK2MXot1Kit7k%3D

    CAS  Google Scholar 

  • R Sobkowiak J Deckert (2003) ArticleTitleCadmium induced changes in growth and cell cycle gene expression in suspension culture cells of soybean Plant Physiol Biochem 41 767–772 Occurrence Handle1:CAS:528:DC%2BD3sXlvVWnu78%3D Occurrence Handle10.1016/S0981-9428(03)00101-3

    Article  CAS  Google Scholar 

  • R Sobkowiak J Deckert (2004) ArticleTitleThe effect of cadmium on cell cycle control in suspension culture cells of soybean Acta Physiol Plant 26 335–344 Occurrence Handle1:CAS:528:DC%2BD2cXpsVSgtLY%3D

    CAS  Google Scholar 

  • H Stals D Inze (2001) ArticleTitleWhen plant cells decide to divide Trends Plant Sci 8 359–364

    Google Scholar 

  • N Suzuki N Kozumi H Sano (2001) ArticleTitleScreening of cadmim-responsive genes in Arabidopsis thaliana Plant Cell Environ 24 1177–1188 Occurrence Handle1:CAS:528:DC%2BD3MXovVKgtrc%3D

    CAS  Google Scholar 

  • S Thomine R Wang JM Ward NM Crawford JI Schroeder (2000) ArticleTitleCadmium and iron transport by members of plant metal transporter family in Arabidopsis with homology to Nramp genes Proc Natl Acad Sci USA 97 4991–4996 Occurrence Handle10781110 Occurrence Handle1:CAS:528:DC%2BD3cXivFKis70%3D Occurrence Handle10.1073/pnas.97.9.4991

    Article  PubMed  CAS  Google Scholar 

  • R Tuteja PL Bhalla MB Singh N Tuteja MK Misra (2001) ArticleTitleMolecular mechanisms of DNA damage and repair: progress in plants Crit Rev Biochem Mol Biol 36 337–397 Occurrence Handle11563486 Occurrence Handle1:CAS:528:DC%2BD3MXntFGmu7Y%3D

    PubMed  CAS  Google Scholar 

  • MP Waalkes (2000) ArticleTitleCadmium carcinogenesis in review J Inorg Chem 79 241–244 Occurrence Handle1:CAS:528:DC%2BD3cXjslyrsLc%3D

    CAS  Google Scholar 

  • M Waisberg P Joseph B Hale D Beyersmann (2003) ArticleTitleMolecular mechanisms of cadmium carcinogenesis Toxicol 192 95–117 Occurrence Handle1:CAS:528:DC%2BD3sXot1Kjt7w%3D Occurrence Handle10.1016/S0300-483X(03)00305-6

    Article  CAS  Google Scholar 

  • S Wang X Shi (2001) ArticleTitleMolecular mechanism of metal toxicity and carcinogenesis Mol Cel Biochem 222 3–9 Occurrence Handle1:CAS:528:DC%2BD3MXnvVehtrw%3D Occurrence Handle10.1023/A:1017918013293

    Article  CAS  Google Scholar 

  • Y Wang J Fang LS Stephen K Rao K Murali (2004) ArticleTitleCadmium inhibits the electron transfer chain and induces reactive oxygen species Free Radical Biol Med 36 1434–1443 Occurrence Handle1:CAS:528:DC%2BD2cXjvVags74%3D Occurrence Handle10.1016/j.freeradbiomed.2004.03.010

    Article  CAS  Google Scholar 

  • LE Williams JK Pittman JL Hall (2000) ArticleTitleEmerging mechanisms for heavy metal transport in plants Biochim Biophys Acta 1465 104–126 Occurrence Handle10748249 Occurrence Handle1:CAS:528:DC%2BD3cXit1Wgtr0%3D

    PubMed  CAS  Google Scholar 

  • S-Y Wu K Culligan M Lamers J Hays (2003) ArticleTitleDissimilar mispair-recognition spectra of Arabidopsis DNA-mismatch-repair proteins MSH2·MSH6 (MutSα) and MSH2·MSH7 (MutSγ) Nucleic Acid Res 31 6027–6034 Occurrence Handle14530450 Occurrence Handle1:CAS:528:DC%2BD3sXotVClsbs%3D

    PubMed  CAS  Google Scholar 

  • K Vandepoele J Raes L Veylder ParticleDe P Rouze S Rombauts D Inze (2002) ArticleTitleGenome-wide analysis of core cell cycle genes in Arabidopsis Plant Cell 14 903–916 Occurrence Handle11971144 Occurrence Handle1:CAS:528:DC%2BD38XjsFWktrs%3D Occurrence Handle10.1105/tpc.010445

    Article  PubMed  CAS  Google Scholar 

  • K Vermeulen DR Bockstale ParticleVan ZN Berneman (2003) ArticleTitleThe cell cycle: a review of regulation, deregulation and therapeutic targets in cancer Cell Prolif 36 131–149 Occurrence Handle12814430 Occurrence Handle1:CAS:528:DC%2BD3sXmtVOitr4%3D

    PubMed  CAS  Google Scholar 

  • K Vido D Spector G Lagniel S Lopez MB Toledano J Labarres (2001) ArticleTitleProteome analysis of the cadmium response in Saccharomyces cerevisiae J Biol Chem 276 8469–8474 Occurrence Handle11078740 Occurrence Handle1:CAS:528:DC%2BD3MXitFKgtL8%3D Occurrence Handle10.1074/jbc.M008708200

    Article  PubMed  CAS  Google Scholar 

  • Ch-M Yeh L-J Hsiao H-J Huang (2004) ArticleTitleCadmium activates a mitogen-activated protein kinase gene and MBP kinase in plant Plant Cell Physiol 45 1306–1312 Occurrence Handle15509854 Occurrence Handle1:CAS:528:DC%2BD2cXptVKltbs%3D Occurrence Handle10.1093/pcp/pch135

    Article  PubMed  CAS  Google Scholar 

  • L Xiong J-K Zhu (2001) ArticleTitleAbiotic stress signal transduction in plants: molecular and genetic perspectives Physiol Plant 112 152–166 Occurrence Handle11454221 Occurrence Handle1:CAS:528:DC%2BD3MXktFeltr4%3D Occurrence Handle10.1034/j.1399-3054.2001.1120202.x

    Article  PubMed  CAS  Google Scholar 

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  1. Laboratory of Plant Ecophysiology, Department of Biology, A.Mickiewicz University, Al. Niepodległości 14, 61-713, Poznań, Poland

    Joanna Deckert

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Deckert, J. Cadmium Toxicity in Plants: Is There any Analogy to its Carcinogenic Effect in Mammalian Cells?. Biometals 18, 475–481 (2005). https://doi.org/10.1007/s10534-005-1245-0

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