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Chemoselective acylation of (hydroxyalkyl)phenols catalyzed by Candida antarctica lipase B

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Abstract

Acylation of (hydroxyalkyl)phenols with vinyl esters by lipase B from Candida antarctica proceeded smoothly in a highly chemoselective manner, affording their alkyl esters exclusively or at least predominantly. The enzyme therefore discriminates between an alcoholic hydroxyl from a phenolic hydroxyl in addition to having versatile catalytic abilities for organic synthesis.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Engineering, Konan University, Higashinada-ku, Kobe, 658-8501, Japan

    Toshifumi Miyazawa, Masato Yamamoto & Hiroshi Danjo

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  1. Toshifumi Miyazawa
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  2. Masato Yamamoto
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  3. Hiroshi Danjo
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Correspondence to Toshifumi Miyazawa.

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Miyazawa, T., Yamamoto, M. & Danjo, H. Chemoselective acylation of (hydroxyalkyl)phenols catalyzed by Candida antarctica lipase B. Biotechnol Lett 35, 625–630 (2013). https://doi.org/10.1007/s10529-012-1124-z

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  • DOI: https://doi.org/10.1007/s10529-012-1124-z

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