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A New Variant of the Mouse Akp1 Locus

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Abstract

A new electrophoretic migration type of alkaline phosphatase 1 (Akp1) was found on the cellulose acetate electrophoresis for kidney and liver homogenates of KWHM mouse, a newly established inbred strain derived from the Korean wild mouse (Mus musculus molossinus). This new type of alkaline phosphatase 1 was distinguished from previously reported AKP1A and AKP1B types in the mouse, and tentatively named AKP1C. In genetic analysis by mating experiments between KWHM and C57BL/6J (AKP1A) or BALB/cA (AKP1B), the phenotypic segregation ratios of AKP1A : AKP1AC : AKP1C or AKP1B : AKP1BC : AKP1C were 1 : 2 : 1 in both groups of F2 generations. It was therefore concluded that AKP1C type is controlled by Akp1c allele which is codominant with Akp1a and Akp1b alleles.

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Authors and Affiliations

  1. ICLAS Monitoring Subcenter Korea, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, Korea

    Chul-Ho Lee, Eun-Hee Kim, Young-Suk Won, Ki-Hoan Nam, Hyoung-Chin Kim & Byung-Hwa Hyun

  2. Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Korea

    Yang-Kyu Choi

  3. Department of Medical Genetics, Experimental Animal Center, College of Medicine, Hallym University, Chunchon, Korea

    Jun-Gyo Suh & Yang-Seok Oh

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  1. Chul-Ho Lee
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  2. Eun-Hee Kim
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  3. Young-Suk Won
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  4. Yang-Kyu Choi
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  5. Ki-Hoan Nam
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  6. Hyoung-Chin Kim
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  9. Yang-Seok Oh
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Correspondence to Hyoung-Chin Kim.

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Lee, CH., Kim, EH., Won, YS. et al. A New Variant of the Mouse Akp1 Locus. Biochem Genet 43, 597–602 (2005). https://doi.org/10.1007/s10528-005-9116-5

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  • DOI: https://doi.org/10.1007/s10528-005-9116-5

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