Parameters of non-spatial and spatial memory were evaluated in sexually mature offspring of outbred rats (females and males F0) consuming a 10% ethanol solution for 30 weeks before mating. We found a significant increase in the recognition index in F1 males and its decrease in F1 females in the novel object recognition test. During the first days of the experiment in T-maze, a decrease in spatial memory was revealed in F1 males, which remained at the trend level until the end of testing; no significant deviations were detected in F1 females. Memory impairment in F1 females was accompanied by a decrease in BDNF level in the hippocampus, but not in the prefrontal cortex. Thus, ethanol consumption by F0 rats before mating led to impairment of long-term working memory only in female F1 offspring.
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Mackiewicz Seghete KL, Cservenka A, Herting MM, Nagel BJ. Atypical spatial working memory and task-general brain activity in adolescents with a family history of alcoholism. Alcohol Clin. Exp. Res. 2013;37(3):390-398. doi: https://doi.org/10.1111/j.1530-0277.2012.01948.x
Shreder ED, Shreder OV, Zabrodina VV, Durnev AD, Seredenin SB. Afobazole modifies the neurotoxic and genotoxic effects in rat prenatal alcoholization model. Bull. Exp. Biol. Med. 2014;157(4):492-495. doi: https://doi.org/10.1007/s10517-014-2599-5
Asimes A, Kim CK, Cuarenta A, Auger AP, Pak TR. Binge drinking and intergenerational implications: parental preconception alcohol impacts offspring development in rats. J. Endocr. Soc. 2018;2(7):672-686. doi: https://doi.org/10.1210/js.2018-00051
Konkov VG, Kudrin VS, Narkevich VB, Efimova AO, Nikiforova TD, Kolik LG. Neurochemical changes in the insular cortex and anterior cingulate cortex in intact males and females of the first generation of rats exposed to chronic ethanol consumption. Neurochem. J. 2022;16(1):85-91. doi: https://doi.org/10.1134/S1819712422010081
Aroeira RI, Vaz SH, Sebastião AM, Valente CA. BDNF modulates glycine uptake in hippocampal synaptosomes by decreasing membrane insertion of glycine transporter 2. Neurochem. Int. 2016;99:94-102. doi: https://doi.org/10.1016/j.neuint.2016.06.007
Scheidt L, Fries GR, Stertz L, Cabral JC, Kapczinski F, de Almeida RM. Ethanol during adolescence decreased the BDNF levels in the hippocampus in adult male Wistar rats, but did not alter aggressive and anxiety-like behaviors. Trends Psychiatry Psychother. 2015;37(3):143-151. doi: https://doi.org/10.1590/2237-6089-2015-0017
Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. Selank, peptide analogue of tuftsin, protects against ethanol-induced memory impairment by regulating of BDNF content in the hippocampus and prefrontal cortex in rats. 2019;167(5):641-644. doi: https://doi.org/10.1007/s10517-019-04588-9
Lowry ER, Kruyer A, Norris EH, Cederroth CR, Strickland S. The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration. Neuroscience. 2013;235:215-225. doi: https://doi.org/10.1016/j.neuroscience.2013.01.029
Mahdinia R, Goudarzi I, Lashkarbolouki T, Salmani ME. Vitamin E attenuates alterations in learning, memory and BDNF levels caused by perinatal ethanol exposure. Nutr. Neurosci. 2021;24(10):747-761. doi: https://doi.org/10.1080/1028415X.2019.1674523
Feng MJ, Yan SE, Yan QS. Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyrosine kinase B in offspring. Brain Res. 2005;1042(2):125-132. doi: https://doi.org/10.1016/j.brainres.2005.02.017
Yu Y, Xu D, Cheng S, Zhang L, Shi Z, Qin J, Zhang Z, Wang H. Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high-fat diet by affecting BDNF-associated pathway. Int. J. Mol. Med. 2020;45(2):365-374. doi: https://doi.org/10.3892/ijmm.2019.4436
Asimes A, Kim CK, Cuarenta A, Auger AP, Pak TR. Binge drinking and intergenerational implications: parental preconception alcohol impacts offspring development in rats. J. Endocr. Soc. 2018;2(7):672-686. doi: https://doi.org/10.1210/js.2018-00051
Przybycien-Szymanska MM, Rao YS, Prins SA, Pak TR. Parental binge alcohol abuse alters F1 generation hypothalamic gene expression in the absence of direct fetal alcohol exposure. PLoS One. 2014;9(2):e89320. doi: https://doi.org/10.1371/journal.pone.0089320
Zheleznyakova GY, Cao H, Schiöth HB. BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis. Behav. Brain Funct. 2016;12(1):17. doi: https://doi.org/10.1186/s12993-016-0101-4
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 5, pp. 568-573, May, 2023
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Solomina, A.S., Kolik, L.G., Rodina, A.V. et al. Chronic Ethanol Consumption by Rats before Mating Affects Working Memory in the Offspring. Bull Exp Biol Med 175, 633–637 (2023). https://doi.org/10.1007/s10517-023-05916-w
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DOI: https://doi.org/10.1007/s10517-023-05916-w