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Regulation of Morphogenetic Processes during Postnatal Development and Physiological Regeneration of the Adrenal Medulla

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Regulation of morphogenetic processes during postnatal development of the rat adrenal medulla was studied. Termination of the adrenal medulla growth was found to be associated with decreased chromaffin cell proliferation, activation of canonical Wnt-signaling pathway, and enhanced expression of Sonic Hedgehog ligand. Analysis of transcription factors associated with pluripotency revealed increased percentage of Oct4-expressing cells by the end of medulla growth and no signs of Sox2 expression. All the cells demonstrating activation of Wnt-signaling and expression of Oct4 and Sonic Hedgehog were found to be highly differentiated chromaffin cells actively producing tyrosine hydroxylase. These findings allow considering the formation of the cell pools for dedifferentiation as a putative mechanism for physiological regeneration of the adrenal medulla.

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Authors and Affiliations

  1. Laboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia

    S. S. Obernikhin, N. V. Yaglova, E. P. Timokhina, S. V. Nazimova & V. V. Yaglov

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  1. S. S. Obernikhin
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  2. N. V. Yaglova
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  3. E. P. Timokhina
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  4. S. V. Nazimova
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  5. V. V. Yaglov
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Corresponding author

Correspondence to V. V. Yaglov.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 98-105, June, 2023

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Obernikhin, S.S., Yaglova, N.V., Timokhina, E.P. et al. Regulation of Morphogenetic Processes during Postnatal Development and Physiological Regeneration of the Adrenal Medulla. Bull Exp Biol Med 175, 549–556 (2023). https://doi.org/10.1007/s10517-023-05903-1

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  • DOI: https://doi.org/10.1007/s10517-023-05903-1

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