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Oligomerization of β-Like DNA Polymerases in the Presence of Fe2+ Ions

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

This work presents data on the relationship between the oligomeric state and catalytic activity of β-like DNA polymerases isolated from three cancer cell lines upon replacement of magnesium ions with iron. It was shown that the suppression of the catalytic activity of β-like DNA polymerases in the presence of divalent iron ions is related to enzyme oligomerization that can be responsible for the suppression of the magnetic isotope effect.

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Authors and Affiliations

  1. N. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    S. V. Stovbun, A. S. Vedenkin, D. V. Zlenko & D. A. Kuznetsov

  2. M. V. Lomonosov Moscow State University, Moscow, Russia

    D. V. Zlenko

  3. N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    A. A. Bukhvostov & D. A. Kuznetsov

Authors
  1. S. V. Stovbun
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  2. A. S. Vedenkin
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  3. D. V. Zlenko
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  4. A. A. Bukhvostov
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  5. D. A. Kuznetsov
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Corresponding author

Correspondence to A. S. Vedenkin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 5, pp. 578-581, May, 2022

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Stovbun, S.V., Vedenkin, A.S., Zlenko, D.V. et al. Oligomerization of β-Like DNA Polymerases in the Presence of Fe2+ Ions. Bull Exp Biol Med 173, 611–614 (2022). https://doi.org/10.1007/s10517-022-05597-x

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  • DOI: https://doi.org/10.1007/s10517-022-05597-x

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