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Dose-Dependent Effects of Intravenous Mesenchymal Stem Cell Transplantation in Rats with Acute Focal Cerebral Ischemia

  • CELL TECHNOLOGIES IN BIOLOGY AND MEDICINECELL MEDICINE
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Bulletin of Experimental Biology and Medicine Aims and scope

Intravenous transplantation of mesenchymal stem (stromal) cells (MSC) is a promising approach to the treatment of ischemic stroke. In the published reports of the already completed preclinical and clinical studies the dosages of transplanted MSC greatly vary. However, the optimal dosage has not been determined. The dose-dependent effect of intravenous MSC transplantation was studied, in rats with experimental cerebral infarction. To this end, 5×105 and 2×106 MSC were intravenously administered 24 h after modeling of acute focal ischemia followed by complex assessment of the therapeutic efficacy over 60 days. The rate and degree of the recovery of neurological functions in rats increased with increasing the dose of injected cells, which confirms the dose-dependent effect of intravenous MSC transplantation.

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Authors and Affiliations

  1. Federal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia

    E. A. Cherkashova, D. D. Namestnikova, I. L. Gubskiy & L. V. Gubsky

  2. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    E. A. Cherkashova, D. D. Namestnikova, I. L. Gubskiy, V. P. Chekhonin & L. V. Gubsky

  3. Federal Research Clinical Center of Specialized Types of Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, Moscow, Russia

    V. A. Revkova

  4. N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

    K. K. Sukhinich

  5. V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia

    P. A. Mel’nikov & V. P. Chekhonin

  6. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    K. N. Yarygin

  7. Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia

    K. N. Yarygin

Authors
  1. E. A. Cherkashova
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  2. D. D. Namestnikova
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  3. I. L. Gubskiy
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  4. V. A. Revkova
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  5. K. K. Sukhinich
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  6. P. A. Mel’nikov
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  7. V. P. Chekhonin
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  8. L. V. Gubsky
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  9. K. N. Yarygin
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Corresponding author

Correspondence to D. D. Namestnikova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 67-72, June, 2022

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Cherkashova, E.A., Namestnikova, D.D., Gubskiy, I.L. et al. Dose-Dependent Effects of Intravenous Mesenchymal Stem Cell Transplantation in Rats with Acute Focal Cerebral Ischemia. Bull Exp Biol Med 173, 514–518 (2022). https://doi.org/10.1007/s10517-022-05573-5

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  • DOI: https://doi.org/10.1007/s10517-022-05573-5

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