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Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus

  • GENETICS
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Bulletin of Experimental Biology and Medicine Aims and scope

Lichen sclerosus of the vulva is a common, but poorly studied disease. We assessed the level of transcriptional activity of APAF1, BAX, BCL2, BIRC5, CCND1, DAPK1, MCL1, and MYC genes encoding products that control apoptosis in the samples of tissues affected by vulvar lichen sclerosus and adjacent control tissues (n=24). Analysis of transcriptional activity was performed by real-time PCR using specific primers and SYBR Green intercalating dye. After the total group was divided by the presence of the concomitant gynecological diseases, a significant increase in the transcriptional activity of the CCND1 gene was revealed in patients with concomitant uterine fibroids. This may indicate the possible role of the activation of mitosis during tumor initiation.

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Authors and Affiliations

  1. Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    E. A. Klimov, N. A. Batashkov, Z. G. Kokaeva & A. V. Tretiakov

  2. University Diagnostic Laboratory, Moscow, Russia

    E. A. Klimov & V. V. Sobolev

  3. Center of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia

    V. V. Sobolev & I. M. Korsunskaya

  4. Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology, Moscow, Russia

    Z. A. Nevozinskaya & I. M. Korsunskaya

  5. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia

    Z. A. Nevozinskaya, T. N. Sukhova & A. Z. Khashukoeva

  6. MEDSI, Moscow, Russia

    O. E. Evina

Authors
  1. E. A. Klimov
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  2. V. V. Sobolev
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  3. N. A. Batashkov
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  4. Z. G. Kokaeva
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  5. A. V. Tretiakov
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  6. Z. A. Nevozinskaya
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  7. I. M. Korsunskaya
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  8. T. N. Sukhova
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  9. O. E. Evina
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  10. A. Z. Khashukoeva
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Corresponding author

Correspondence to I. M. Korsunskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 12, pp. 735-739, December, 2021

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Klimov, E.A., Sobolev, V.V., Batashkov, N.A. et al. Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus. Bull Exp Biol Med 172, 734–737 (2022). https://doi.org/10.1007/s10517-022-05467-6

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  • DOI: https://doi.org/10.1007/s10517-022-05467-6

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