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Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats

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We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the cellular product reduces the proinflammatory background at the early stages of the experiment and increases the content proangiogenic factors.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. P. Lykov, N. A. Bondarenko, O. V. Poveshchenko, A. V. Kabakov, M. A. Surovtseva, I. I. Kim, O. V. Kazakov, A. F. Poveshchenko & E. V. Yankaite

  2. E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    A. P. Lykov, N. A. Bondarenko, O. V. Poveshchenko, M. A. Surovtseva, I. I. Kim & A. F. Poveshchenko

Authors
  1. A. P. Lykov
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  2. N. A. Bondarenko
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  3. O. V. Poveshchenko
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  4. A. V. Kabakov
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  5. M. A. Surovtseva
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  6. I. I. Kim
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  7. O. V. Kazakov
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  8. A. F. Poveshchenko
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  9. E. V. Yankaite
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Corresponding author

Correspondence to A. P. Lykov.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 3, pp. 185-190, September, 2019

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Lykov, A.P., Bondarenko, N.A., Poveshchenko, O.V. et al. Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats. Bull Exp Biol Med 168, 150–155 (2019). https://doi.org/10.1007/s10517-019-04666-y

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  • DOI: https://doi.org/10.1007/s10517-019-04666-y

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