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Cytotoxic Activity of Peripheral Blood NK Cells towards Trophoblast Cells during Pregnancy

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Bulletin of Experimental Biology and Medicine Aims and scope

We evaluated cytotoxic activity of peripheral blood NK cells towards trophoblast cells. NK cells either isolated or in the composition of mononuclear cell fraction, caused death of trophoblast cells. In women with physiological pregnancy, the cytotoxic effect of NK cells present in mononuclear cell fraction preincubated with IL-2 was lower than in nonpregnant women, who had never been pregnant previously, and in fertile women. Cytotoxic activity of isolated NK cells preincubated with IL-2 in fertile women was lower than in nonpregnant women, who had never been pregnant previously.

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Authors and Affiliations

  1. D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia

    V. A. Mikhailova, D. O. Bazhenov, L. P. Viazmina, A. O. Agnaeva, O. N. Bespalova, S. A. Sel’kov & D. I. Sokolov

Authors
  1. V. A. Mikhailova
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  2. D. O. Bazhenov
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  3. L. P. Viazmina
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  4. A. O. Agnaeva
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  5. O. N. Bespalova
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  6. S. A. Sel’kov
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  7. D. I. Sokolov
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Corresponding author

Correspondence to V. A. Mikhailova.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 254-261, December, 2018

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Mikhailova, V.A., Bazhenov, D.O., Viazmina, L.P. et al. Cytotoxic Activity of Peripheral Blood NK Cells towards Trophoblast Cells during Pregnancy. Bull Exp Biol Med 166, 567–573 (2019). https://doi.org/10.1007/s10517-019-04393-4

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  • DOI: https://doi.org/10.1007/s10517-019-04393-4

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