A cross-sectional study of universe sample of patients (N=135; mean age —49.7±0.8 years) with metabolic syndrome yielded the incidence of cardiac autonomic neuropathy of 37.5%. The pathogenetic peculiarities were revealed for the onset and development of this neuropathy. At the early stages, the progress of cardiac autonomic neuropathy closely correlated with elevation of blood glucose, while endothelial dysfunction progressing at the later period against the background of persistent hyperglycemia is viewed as an extra factor contributing to the development of this disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boitsov SA, Dovgalevskii PYa, Gridnev VI, Oshchepkova EV, Dmitriev VA. Comparative analysis of Russian and foreign registers of acute coronary syndrome. Kardiol. Vestn. 2010;5(1):82-86. Russian.
Golovacheva VA, Parfyonov VA. Management of patients with diabetic polyneuropathy: current guidelines for diagnosis and treatment, prospects for pharmacotherapy. Med. Sovet. 2015;(18):24-29. Russian.
Udut VV, Kseneva SI, Borodulina EV, Trifonova OY. Patent RU No. 2585741. Method for early diagnosis of autonomic cardiac neuropathy in patients with arterial hypertension and metabolic disorders. Bull. No. 16. Published June 10, 2016.
Politova EA, Logachev MF, Zavadenko NN. Diabetic peripheral neuropathy (review). Detskaya Bol’nitsa. 2012;(3):54-59. Russian.
Tanashyan MM, Ionova VG, Orlov SV, Omelchenko NG, Shabalina AA, Kostyreva MV. Chronic cerebrovascular diseases, metabolic syndrome, and the hemorrheological and hemostatic systems. Ter. Arkhiv. 2010;82(10):19-24. Russian.
Chernikova NA. Cardiovascular form of diabetic autonomic neuropathy. Effect. Endokrinol. 2013;(5):44-49. Russian.
Alexander CM, Landsman PB, Teutsch SM, Haffner SM; Third National Health and Nutrition Examination Survey (NHANES III); National Cholesterol Education Program (NCEP). NCEPdefined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes. 2003;52(5):1210-1214.
Celermajer DS. Non-invasive detection of endothelial dysfunction on children and adults at risk of atherosclerosis. Lancet. 1992;340:1111-1115.
Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996;93(5):1043-1065.
IDF Clinical Guidеlines Task Forse. Global Guideline for Type 2 Diabetes: recommendations for standard, comprehensive, and minimal care. Diabet. Med. 2006;23(6):579-593.
Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017;40(1):136-154.
Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115(3):387-397.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 7, pp. 15-20, July, 2017
Rights and permissions
About this article
Cite this article
Kseneva, S.I., Borodulina, E.V., Trifonova, O.Y. et al. Pathogenetic Mechanisms of Outbreak and Development of Cardiac Autonomic Neuropathy in Patients with Metabolic Syndrome. Bull Exp Biol Med 164, 10–14 (2017). https://doi.org/10.1007/s10517-017-3914-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3914-8