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Reconstruction of Ligament and Tendon Defects Using Cell Technologies

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.

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Authors and Affiliations

  1. N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia

    R. K. Chailakhyan, Yu. V. Gerasimov, A. G. Grosheva & I. L. Moskvina

  2. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    A. B. Shekhter, S. V. Ivannikov, V. I. Tel’pukhov, D. S. Suslin, A. M. Tonenkov & P. V. Panyushkin

  3. Institute of Photonics Technologies, Russian Academy of Sciences, Federal Research Center “Crystallography and Photonics”, Russian Academy of Sciences, Moscow, Russia

    N. N. Vorob’eva & V. N. Bagratashvili

Authors
  1. R. K. Chailakhyan
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  2. A. B. Shekhter
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  3. S. V. Ivannikov
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  4. V. I. Tel’pukhov
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  5. D. S. Suslin
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  6. Yu. V. Gerasimov
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  7. A. M. Tonenkov
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  8. A. G. Grosheva
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  9. P. V. Panyushkin
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  10. I. L. Moskvina
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  11. N. N. Vorob’eva
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  12. V. N. Bagratashvili
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Corresponding author

Correspondence to R. K. Chailakhyan.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 254-259, October, 2016

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Chailakhyan, R.K., Shekhter, A.B., Ivannikov, S.V. et al. Reconstruction of Ligament and Tendon Defects Using Cell Technologies. Bull Exp Biol Med 162, 563–568 (2017). https://doi.org/10.1007/s10517-017-3660-y

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  • DOI: https://doi.org/10.1007/s10517-017-3660-y

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