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Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus

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The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, V. V. Klimontov, L. N. Rachkovskaya, V. I. Konenkov & E. L. Zavyalov

  2. Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, V. V. Klimontov, L. N. Rachkovskaya, V. I. Konenkov & E. L. Zavyalov

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  1. S. V. Michurina
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  2. I. Yu. Ishchenko
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  3. S. A. Arkhipov
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  4. V. V. Klimontov
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  5. L. N. Rachkovskaya
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  6. V. I. Konenkov
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  7. E. L. Zavyalov
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Corresponding author

Correspondence to S. V. Michurina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 8, pp. 238-241, August, 2016

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Michurina, S.V., Ishchenko, I.Y., Arkhipov, S.A. et al. Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus. Bull Exp Biol Med 162, 269–272 (2016). https://doi.org/10.1007/s10517-016-3592-y

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  • DOI: https://doi.org/10.1007/s10517-016-3592-y

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