Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new location test. In the same tests, CA-7050× demonstrated the cognitive-stimulating and anxiolytic effects on transgenic 5×FAD mice.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
S. O. Bachurin, Vopr. Med. Khim., 47, No. 2, 155-197 (2001).
M. L. Belen’ky, Elements of Quantitative Estimation of Pharmacological Effect [in Russian], Leningrad (1963).
V. V. Grigor’ev, A. N. Proshin, A. S. Kinzirskii, and S. O. Bachurin, Usp. Khim., 78, No. 5, 524-534 (2009).
V. S. Kokhan, A. V. Bolkunov, A. A. Ustyugov, et al., Zh. Vyssh. Nervn. Deyat., 61, No. 1, 85-93 (2011).
L. V. Maksimova, Vestn. Belorusskogo Gos. Univer. Ser. 2, Chim. Biol. Geogr., No. 3, 54-58 (2008).
K. K. Sidorov, Toksikol. Nov. Prom. Khim. Veshch., No. 13, 47-51 (1973).
M. Antunes and G. Biala, Cogn. Process, 13, No. 2, 93-110 (2012).
J. Camarasa, T. Rodrigo, D. Pubill, and E. Escubedo, Pharmacol. Res., 62, No. 5, 450-456 (2010).
A. N. Carey, A. M. Lyons, C. F. Shay, et al., J. Neurosci., 29, No. 13, 4293-4300 (2009).
R. S. Doody, S. I. Gavrilova, M. Sano, et al., Lancet, 372, 207-215 (2008).
H. de Jesus-Cortes, P. Xu, J. Drawbridge, et al., Proc. Natl Acad. Sci. USA, 109, No. 42, 17,010-17,015 (2012).
J. M. Marques, L. A. Olsson, S. O. Ogren, and K. Dahlborn, Physiol. Behav., 93, Nos. 1-2, 139-147 (2008).
T. V. Mukhina, S. O. Bachurin, N. N. Lermontova, and N. S. Zefirov, Behav. Res. Meth. Instr. Comput., 33, No. 3, 371-380 (2001).
H. Oakley, S. L. Cole, S. Logan, et al., J. Neurosci., 26, No. 40, 10,129-10,140 (2006).
O. M. Peters, N. Connor-Robson, V. B. Sokolov et al., J. Alzheimers Dis., 33, No. 4, 1041-1049 (2013).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 455-459, October 2015
Rights and permissions
About this article
Cite this article
Nikolaeva, N.S., Sokolov, V.B., Aksinenko, A.Y. et al. Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles. Bull Exp Biol Med 160, 455–458 (2016). https://doi.org/10.1007/s10517-016-3195-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3195-7