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The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome

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Bulletin of Experimental Biology and Medicine Aims and scope

The expression of dopamine receptor (DRD), Nurr1 transcription factor (NR4A2), and α-sinucleine (SNCA) genes in peripheral blood lymphocytes is evaluated. The results indicate that alcohol dependence is associated with high expression of SNCA and DRD4 (signifi cantly higher than in the control group) and is not associated with changes in the work of NR4A2 and DRD3 genes. The levels of DRD3 and DRD4 mRNA form a positive linear correlation (p≤0.05). The expression of SNCA and DRD4 genes can serve as an important peripheral marker of alcohol dependence development, which is essential for antipsychotic therapy.

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References

  1. A. E. Taraskina, S. N. Pchelina, M. L. Remizov, et al., Med. Genetika, 5, No. 10, 16-20 (2006).

    Google Scholar 

  2. A. E. Taraskina, S. N. Pchelina, E. M. Krupitsky, et al., Obozr. Psikhiatr. Med. Psikhol. im. V. M. Bekhtereva, No. 1, 62-70 (2009).

  3. A. E. Taraskina, M. N. Morozova, N. V. Bychkova, et al., Ross. Immunol. Zh., 6, No. 3, 273-280 (2012).

    Google Scholar 

  4. F. R. Buttarelli, A. Fanciulli, C. Pellicano, and F. E. Pontieri, Curr. Neuropharmacol., 9, No. 2, 278-288 (2011).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. J. W. Cave and H. Baker, Adv. Exp. Biol. Med., 651, 15-35 (2009).

    Article  CAS  Google Scholar 

  6. C. Czermak, M. Lehofer, E. M. Wagner, et al., Addiction, 99, No. 2, 251-257 (2004).

    Article  PubMed  Google Scholar 

  7. D. M. Dick and T. Faroud, Alcohol. Clin. Exp. Res., 27, No. 5, 868-879 (2003).

    Article  PubMed  Google Scholar 

  8. A. L. Frederick and G. D. Stanwood, Dev. Neurosci., 31, Nos. 1-2, 7-22 (2009).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. M. D. Köhnke, Biochem. Pharmacol., 75, No. 1, 160-177 (2008).

    Article  PubMed  Google Scholar 

  10. J. Langan, D. Martin, P. Shajahan, and D. J. Smith, BMC Psychiatry, 12, 214 (2012).

    Article  PubMed Central  PubMed  Google Scholar 

  11. C. Missale, S. R. Nash, S. W. Robinson, et al., Physiol. Rev., 78, No. 1, 189-225 (1998).

    CAS  PubMed  Google Scholar 

  12. J. Spence, T. Liang, T. Foroud, et al., Addict. Biol., 10, No. 1, 47-51 (2005).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. B. Söderpalm, E. Löf, and M. Ericson, Pharmacopsychiatry, 42, Suppl. 1, S87-S94 (2009).

    Article  PubMed  Google Scholar 

  14. V. Vengeliene, A. Bilbao, A. Molander, and R. Spanagel, J. Pharmacol., 154, No. 2, 299-315 (2008).

    CAS  Google Scholar 

  15. T. I. Uzbay, Alcohol Alcohol, 47, No. 1, 33-41 (2012).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia

    A. E. Taraskina, M. N. Grunina, A. M. R. Zabotina & A. L. Schwartzman

  2. I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of Russia, St. Petersburg, Russia

    A. E. Taraskina

  3. V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia

    A. E. Taraskina, F. Nasyrova, M. V. Ivanov & E. M. Krupitsky

Authors
  1. A. E. Taraskina
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  2. M. N. Grunina
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  3. A. M. R. Zabotina
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  4. F. Nasyrova
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  5. M. V. Ivanov
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  6. E. M. Krupitsky
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  7. A. L. Schwartzman
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Corresponding author

Correspondence to A. E. Taraskina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 8, pp. 240-244, August, 2015

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Taraskina, A.E., Grunina, M.N., Zabotina, A.M.R. et al. The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome. Bull Exp Biol Med 160, 271–274 (2015). https://doi.org/10.1007/s10517-015-3147-7

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  • DOI: https://doi.org/10.1007/s10517-015-3147-7

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