Enzyme immunoassay showed that the content of matrix metalloproteinases (MMP) 2 and 7 in tumors was higher than in the adjacent histologically intact tissue in 91 and 76% patients with breast cancer, respectively, while MMP-9 levels in the tumor and intact tissue were virtually the same. Serum concentrations of MMP-2 and MMP-7 did not correlate with their levels in the tumors, were within the normal range, and virtually did not decrease after removal of the primary tumor. Serum levels of MMP-9 in patients were significantly lower than in the control and increased after surgery in 85% patients. No clear-cut relationship between the studied parameters and clinical morphological prognostic factors of breast cancer was detected.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 3, pp. 334–338, March, 2011
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Katunina, A.I., Gershtein, E.S., Ermilova, V.D. et al. Matrix Metalloproteinases 2, 7, and 9 in Tumors and Sera of Patients with Breast Cancer. Bull Exp Biol Med 151, 359–362 (2011). https://doi.org/10.1007/s10517-011-1330-z
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DOI: https://doi.org/10.1007/s10517-011-1330-z