Effects of ascorbic acid on calcium homeostasis of human laryngeal carcinoma cells were studied. Intracellular concentration of free calcium and intracellular pH were measured by fluorescent analysis. Ascorbic acid in concentrations of 3–10 mM caused pH drop and sharply increased concentrations of free Ca ions in HEp-2 cells. Intracellular concentration of free Ca ions resulted from Ca ion release from the thapsigargin-sensitive Ca depots.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 4, pp. 452–455, April, 2009
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Martinovich, G.G., Martinovich, I.V. & Cherenkevich, S.N. Effects of Ascorbic Acid on Calcium Signaling in Tumor Cells. Bull Exp Biol Med 147, 469–472 (2009). https://doi.org/10.1007/s10517-009-0555-6
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DOI: https://doi.org/10.1007/s10517-009-0555-6