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Effect of histochrome on brain vessels and research and exploratory activity of senescence-accelerated OXYS rats

  • Biogerontology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Changes in the diameter of brain vessels and intensity of collateral blood flow typical of chronic ischemia were detected by magnetic resonance imaging in senescence-accelerated OXYS rats demonstrating reduced (compared to Wistar rats) research and exploratory activity. Histochrome (antioxidant drug) produced positive effects on cerebral vessels in OXYS rats by stimulating collateral blood flow and acting as a vasodilator agent. Analysis of correlations showed that these effects of histochrome were closely related to its capacity to activate research and exploratory activity and reduce anxiety of OXYS rats in the open field test.

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Authors and Affiliations

  1. Pacific Institute of Organic Biochemistry, Far Eastern Division of Russian Academy of Sciences, Vladivostok

    I. G. Agafonova, N. P. Mishchenko, E. L. Chaikina & V. A. Stonik

  2. Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk

    N. G. Kolosova

Authors
  1. I. G. Agafonova
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  2. N. G. Kolosova
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  3. N. P. Mishchenko
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  4. E. L. Chaikina
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  5. V. A. Stonik
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Corresponding author

Correspondence to I. G. Agafonova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 4, pp. 446–450, April, 2007

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Agafonova, I.G., Kolosova, N.G., Mishchenko, N.P. et al. Effect of histochrome on brain vessels and research and exploratory activity of senescence-accelerated OXYS rats. Bull Exp Biol Med 143, 467–471 (2007). https://doi.org/10.1007/s10517-007-0158-z

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  • DOI: https://doi.org/10.1007/s10517-007-0158-z

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