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Proliferative activity of cells in mouse thymus and spleen under different diurnal regimens of interleukin-2 administration

  • Experimental Biology
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Abstract

Circadian variations in spontaneous and concanavalin A-stimulated proliferation of mouse thymocytes and splenocytes were studied after administration of recombinant interleukin-2 at different times of day. Differences were revealed in the effect of morning and evening treatment with the cytokine. The time of injection corresponded to various phases of the natural circadian rhythm of endogenous interleukin-2 production, which probably contributes to diurnal differences in the influence of this cytokine.

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Authors and Affiliations

  1. Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    I. G. Kovshik & A. V. Shurlygina

  2. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    V. A. Trufakin

  3. Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    A. N. Silkov & S. V. Sennikov

Authors
  1. I. G. Kovshik
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  2. A. N. Silkov
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  3. S. V. Sennikov
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  4. A. V. Shurlygina
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  5. V. A. Trufakin
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Corresponding author

Correspondence to A. V. Shurlygina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 7, pp. 110–113, July, 2006

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Kovshik, I.G., Silkov, A.N., Sennikov, S.V. et al. Proliferative activity of cells in mouse thymus and spleen under different diurnal regimens of interleukin-2 administration. Bull Exp Biol Med 142, 98–101 (2006). https://doi.org/10.1007/s10517-006-0302-1

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  • DOI: https://doi.org/10.1007/s10517-006-0302-1

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