Abstract
Antibodies against calcium-binding protein S100 (AB-S100) 1.5-fold increased, while quinine 2-fold decreased the frequency of action potential generation in B4 and B6 neurons. Application of quinine against the background of AB-S100 treatment returned this parameter to the initial level. Pretreatment with AB-S100 in low doses prevents changes the frequency of action potential generation induced by application of AB-S100 in the initial dilution. The duration of action potential increased by 1.6 times after application of AB-S100 and quinine, while after application of quinine increased this parameter by more than 6 times. AB-S100 decreased maximum inward current by 20%. Our experiments demonstrated a modulating effect of combined administration of AB-S100 and its low doses on the membrane effects of quinine.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 7, pp. 4–7, July, 2006
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Epstein, O.I., Shtark, M.B., Andrianov, V.V. et al. Modulatory action of combined treatment with antibodies against S100 protein and low doses of this protein on membrane effects of quinine. Bull Exp Biol Med 142, 1–4 (2006). https://doi.org/10.1007/s10517-006-0275-0
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DOI: https://doi.org/10.1007/s10517-006-0275-0