Skip to main content
Log in

Enzymes of estrogen metabolism in endometrial cancer

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Activities of estrogen metabolism enzymes (aromatase, 2-and 4-estrogen hydroxylases, catechol-O-methyltransferase, and glutathione transferase) were studied by modern biochemical methods in tumors of patients with endometrial cancer. Relationships between enzyme activities and body weight index, age of menarche, stage of the disease, tumor histotype, differentiation degree, and depth of invasion into the myometrium were detected. The detected relationships between enzyme activities and serum concentrations of estradiol and progesterone and level of estrogen receptors in tumor tissue attest to hormone dependence of aromatase, estrogen hydroxylases, and glutathione transferase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. S. Bassalyk, E. S. Gerstein, N. E. Kushlinskii, et al., Detection of Steroid Hormone Receptors in Hormone-Dependent Tumors and Prospective Endocrine Therapy (Methodological Recommendations) [in Russian], Moscow (1987).

  2. L. M. Berstein, Hormonal Carcinogenesis [in Russian], St. Petersburg (2000).

  3. L. M. Berstein, A. E. Chernobrovkina, V. B. Gamayunova, et al., Vopr. Onkol., 49, No. 1, 55–59 (2003).

    PubMed  CAS  Google Scholar 

  4. V. Z. Lankin, A. K. Takhaze, and A. L. Koval’skaya, Dokl. Akad. Nauk SSSR, 261, No. 6, 1467–1470 (1981).

    PubMed  CAS  Google Scholar 

  5. Z. Sh. Gilyazutdinova, M. K. Mikhailov, Eds., Oncology: Manual for Physicians [in Russian], Moscow (2000).

  6. E. L. Cavalieri, E. C. Rogan, and D. Chakravarti, Cell. Mol. Life Sci., 59, 665–681 (2002).

    Article  PubMed  CAS  Google Scholar 

  7. C. N. Theron, V. A. Russel, and J. J. Taljard, J. Steroid Biochem., 25, No. 4, 585–591 (1986).

    Article  PubMed  CAS  Google Scholar 

  8. G. Zurcher and M. Da Prada, J. Neurochem., 38, No. 1, 191–195 (1982).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 202–204, February, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bochkareva, N.V., Kolomiets, L.A., Kondakova, I.V. et al. Enzymes of estrogen metabolism in endometrial cancer. Bull Exp Biol Med 141, 240–242 (2006). https://doi.org/10.1007/s10517-006-0138-8

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0138-8

Key Words

Navigation