Abstract
A new taurine derivative chlorohydrate-N-isopropylamide-2-(1-phenylethyl)aminoethanesulfonic acid normalized energy metabolism, inhibited lipid peroxidation, and reactivated antioxidant enzymes in the brain of rats exposed to ischemia. This taurine derivative decreased the mortality rate of animals with ischemic changes in cerebral circulation. The test compound was more potent than piracetam in producing the cerebroprotective effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 1, pp. 49–52, January, 2006
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Sapronov, N.S., Bul’on, V.V., Krylova, I.B. et al. Cerebroprotective effect of a new taurine derivative during cerebral ischemia. Bull Exp Biol Med 141, 44–47 (2006). https://doi.org/10.1007/s10517-006-0089-0
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DOI: https://doi.org/10.1007/s10517-006-0089-0