Abstract
We demonstrated changes in the sensitivity of the adenylate cyclase signaling system to biogenic amines (adrenoceptor agonists and serotonin) underwent a change in skeletal muscles of rats with 30-day streptozotocin-induced diabetes. Isoproterenol had a less significant stimulatory effect on adenylate cyclase in diabetic rats. Hormonal signals via Gi proteins were suppressed in animals with diabetes, which determined a greater stimulatory effect of norepinephrine and serotonin on adenylate cyclase. Hormones less significantly increased guanosine triphosphate-binding activity of G proteins in diabetic rats, which reflects the impairment of their functional coupling with receptors.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 9, pp. 286–290, September, 2005
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Shpakov, A.O., Kuznetsova, L.A., Plesneva, S.A. et al. Molecular Mechanisms of Modified Sensitivity of the Adenylate Cyclase Signaling System to Biogenic Amines during Streptozotocin-Induced Diabetes. Bull Exp Biol Med 140, 304–308 (2005). https://doi.org/10.1007/s10517-005-0474-0
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DOI: https://doi.org/10.1007/s10517-005-0474-0