Abstract
To describe patterns of depressive symptoms across 10-years by HIV status and to determine the associations between depressive symptom patterns, HIV status, and clinical profiles of persons living with HIV from the Multicenter AIDS Cohort Study (N = 980) and Women’s Interagency HIV Study (N = 1744). Group-based trajectory models were used to identify depressive symptoms patterns between 2004 and 2013. Multinomial logistic regressions were conducted to determine associations of depression risk patterns. A 3-group model emerged among HIV-negative women (low: 58%; moderate: 31%; severe: 11%); 5-groups emerged among HIV-positive women (low: 28%; moderate: 31%; high: 25%; decreased: 7%; severe: 9%). A 4-group model emerged among HIV-negative (low: 52%; moderate: 15%; high: 23%; severe: 10%) and HIV-positive men (low: 34%; moderate: 34%; high: 22%; severe: 10%). HIV+ women had higher odds for moderate (adjusted odds ratio [AOR] 2.10, 95% CI 1.63–2.70) and severe (AOR 1.96, 95% CI 1.33–2.91) depression risk groups, compared to low depression risk. HIV+ men had higher odds for moderate depression risk (AOR 3.23, 95% CI 2.22–4.69), compared to low risk. The Framingham Risk Score, ART use, and unsuppressed viral load were associated with depressive symptom patterns. Clinicians should consider the impact that depressive symptoms may have on HIV prognosis and clinical indicators of comorbid illnesses.
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References
Arseniou S, Arvaniti A, Samakouri M. HIV infection and depression. Psychiatry Clin Neurosci. 2014;68(2):96–109.
Nanni MG, Caruso R, Mitchell AJ, Meggiolaro E, Grassi L. Depression in HIV infected patients: a review. Curr Psychiatry Rep. 2014;17(1):1–11.
Beidas RS, Birkett M, Newcomb ME, Mustanski B. Do psychiatric disorders moderate the relationship between psychological distress and sexual risk-taking behaviors in young men who have sex with men? A longitudinal perspective. AIDS Patient Care STDS. 2012;26(6):366–74.
Seth P, Raiji PT, DiClemente RJ, Wingood GM, Rose E. Psychological distress as a correlate of a biologically confirmed STI, risky sexual practices, self-efficacy and communication with male sex partners in African-American female adolescents. Psychol Health Med. 2009;14:291–300.
Williams CT, Latkin CA. The role of depressive symptoms in predicting sex with multiple and high-risk partners. JAIDS. 2005;38:69–73.
Gold JA, Grill M, Peterson J, et al. Longitudinal characterization of depression and mood states beginning in primary HIV infection. AIDS Behav. 2014;18(6):1124–32.
Braithwaite RS, Fang Y, Tate J, et al. Do alcohol misuse, smoking, and depression vary concordantly or sequentially? A longitudinal study of HIV-infected and matched uninfected veterans in care. AIDS Behav. 2016;20(3):566–72.
Palfai TP, Cheng DM, Coleman SM, Bridden C, Krupitsky E, Samet JH. The influence of depressive symptoms on alcohol use among HIV-infected Russian drinkers. Drug Alcohol Depend. 2014;134:85–91.
Chander G, Himelhoch S, Moore R. Substance abuse and psychiatric disorders in HIV-positive patients: epidemiology and impact on antiretroviral therapy. Drugs. 2006;66(6):769–89.
Lightfoot M, Rogers T, Goldstein R, et al. Predictors of substance use frequency and reductions in seriousness of use among persons living with HIV. Drug Alcohol Depend. 2005;77(2):129–38.
Gonzalez JS, Batchelder AW, Psaros C, Safren SA. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. JAIDS. 2013;58(2):181–7.
Springer SA, Dushaj A, Azar MM. The impact of DSM-IV mental disorders on adherence to combination antiretroviral therapy among adult persons living with HIV/AIDS: a systematic review. AIDS Behav. 2012;16(8):2119–43.
Horberg MA, Silverberg MJ, Hurley LB, et al. Effects of depression and selective serotonin reuptake inhibitor use on adherence to highly active antiretroviral therapy and on clinical outcomes in HIV-infected patients. JAIDS. 2008;47(3):384–90.
Balderson BH, Grothaus L, Harrison RG, McCoy K, Mahoney C, Catz S. Chronic illness burden and quality of life in an aging HIV population. AIDS Care. 2013;25(4):451–8.
Schwartz RM, Mansoor A, Wilson TE, et al. Chronic depressive symptoms and Framingham coronary risk in HIV-infected and HIV-uninfected women. AIDS Care. 2012;24(3):394–403.
White JR, Chang CC, So-Armah KA, et al. Depression and human immunodeficiency virus infection are risk factors for incident heart failure among veterans: veterans Aging Cohort Study. Circulation. 2015;132(17):1630–8.
Parruti G, Vadini F, Sozio F, et al. Psychological factors, including alexithymia, in the prediction of cardiovascular risk in HIV infected patients: results of a cohort study. PLoS ONE. 2013;8(1):e54555.
Pyra M, Weber KM, Wilson TE, et al. Sexual minority women and depressive symptoms throughout adulthood. Am J Public Health. 2014;104(12):e83–90.
Zeger SL, Liang KY. Longitudinal data analysis for discrete and continuous outcomes. Biometrics. 1986;42(1):121–30.
Richardson J, Barkan S, Cohen M, et al. Experience and covariates of depressive symptoms among a cohort of HIV infected women. Soc Work Health Care. 2001;32(4):93–111.
Centers for Disease Control and Prevention. HIV among women. Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, Sexual Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention; 2015. http://www.cdc.gov/hiv/group/gender/women/index.html#refa. Accessed January 25, 2016.
Altemus M, Sarvaiya N, Neill Epperson C. Sex differences in anxiety and depression clinical perspectives. Front Neuroendocrinol. 2014;35(3):320–30.
Jennings WG, Meade C. Group-based trajectory modeling. Oxford Handbooks Online; 2016. Access December 17, 2016 at http://www.oxfordhandbooks.com/view/10.1093/oxfordhb/9780199935383.001.0001/oxfordhb-9780199935383-e-96?print=pdf.
Kaslow RA, Ostrow DG, Detels R, Phair JP, Polk BF, Rinaldo CR. The multicenter AIDS cohort study: rationale, organization, and selected characteristics of the participants. Am J Epidemiology. 1987;126(2):310–8.
Detels R, Phair JP, Saah AJ, Rinaldo CR, Murioz A, Kaslow RA, et al. Recent scientific contributions to understanding HIV/AIDS from the multicenter AIDS cohort study. J Epidemiol. 1992;2(2 supp):11–9.
Dudley J, Jin S, Hoover D, Metz S, Thackeray R, Chmiel J. The multicenter AIDS cohort study: retention after 9 1/2 years. Am J Epidemiol. 1995;142(3):323–30.
Barkan SE, Melnick SL, Preston-Martin S, et al. The women’s interagency HIV study: wIHS collaborative study group. Epidemiology. 1998;9:117–25.
Bacon MC, von Wyl V, Alden C, et al. The women’s interagency HIV study: an observational cohort brings clinical sciences to the bench. Clin Diagn Lab Immunol. 2005;12:1013–9.
Radloff LS. The CES-D Scale A self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1(3):385–401.
Hann D, Winter K, Jacobsen P. Measurement of depressive symptoms in cancer patients: evaluation of the Center for Epidemiological Studies Depression Scale (CES-D). J Psychosom Res. 1999;46(5):437–43.
Verdier-Taillefer MH, Gourlet V, Fuhrer R, Alpérovitch A. Psychometric properties of the Center for Epidemiologic Studies-Depression scale in multiple sclerosis. Neuroepidemiology. 2001;20(4):262–7.
Gay CL, Kottorp A, Lerdal A, Lee KA. Psychometric limitations of the Center for Epidemiologic Studies-Depression Scale for assessing depressive symptoms among adults with HIV/AIDS: a Rasch analysis. Depress Res Treat. 2016;2016:2824595.
AIDSinfo. Virologic failure: adult and adolescent ARV guidelines; 2016. Retrieved from https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/15/virologic-failure.
Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97(18):1837–47.
Center for Disease Prevention and Control. Alcohol & Public Health; 2016. Retrieved at https://www.cdc.gov/alcohol/faqs.htm.
Hsu H-C. Group-based trajectories of depressive symptoms and the predictors in the older population. Int J Geriatr Psychiatry. 2012;27(8):854–62.
Liang J, Xu X, Quiñones AR, Bennett JM, Ye W. Multiple trajectories of depressive symptoms in middle and late life: racial/ethnic variations. Psychol Aging. 2011;26(4):761–77.
Montagnier D, Dartigues J-F, Rouillon F, Pérès K, Falissard B, Onen F. Ageing and trajectories of depressive symptoms in community-dwelling men and women. Int J Geriatr Psychiatry. 2014;29(7):720–9.
Andruff H, Carraro N, Thompson A, Gaudreau P, Louvet B. Latent class growth modeling: a tutorial. Tutor Quant Methods Psychol. 2009;5:11–24.
Choi SKY, Boyle E, Burchell AN, Gardner S, Collins E, Grootendorst P, et al. Validation of six short and ultra-short screening instruments for depression for people living with HIV in Ontario: results from the Ontario HIV treatment network cohort study. PLoS ONE. 2015;10(11):e0142706.
Gater R, Tansella M, Korten A, Tiemens BG, Mavreas VG, Olatawura MO. Sex differences in the prevalence and detection of depressive and anxiety disorders in general health care settings: report from the World Health Organization collaborative study on psychological problems in general health care. Arch Gen Psychiatry. 1998;55(5):405–13.
Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the united states: results from the national comorbidity survey. Arch Gen Psychiatry. 1994;51(1):8–19.
Weissman MM, Bland RC, Canino GJ, et al. Cross-national epidemiology of major depression and bipolar disorder. JAMA. 1996;276(4):293–9.
Reis RK, Haas VJ, dos Santos CB, Teles SA, Galvão MTG, Gir E. Symptoms of depression and quality of life of people living with HIV/AIDS. Rev Lat Am Enfermagem. 2011;19(4):874–81.
Pecoraro A, Mimiaga M, O’Cleirigh C, et al. Depression, substance use, viral load, and CD4+ count among patients who continued or left antiretroviral therapy for HIV in St Petersburg, Russian Federation. AIDS Care. 2015;27(1):86–92.
Mateen FJ, Post WS, Sacktor N, et al. Multicenter AIDS cohort study (MACS) investigators. Long-term predictive value of the Framingham risk score for stroke in HIV-positive vs HIV-negative men. Neurology. 2013;81(24):2094–102.
Friis-Møller N, Thiébaut R, Reiss P, et al. Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study. Eur J Cardiovasc Prev Rehabil. 2010;17(5):491–501.
Acknowledgements
This work was supported by Grant F31 AA024064 from the National Institute of Alcoholism and Alcohol Abuse of the National Institutes of Health (Natalie Kelso-Chichetto), Grant U01-AI-103397 from the Miami Women’s Interagency HIV Study (WIHS) (support for Robert Cook), and Grant F31 DA039810 from the National Institute on Drug Abuse (Chukwuemeka Okafor).
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Data in this manuscript were collected by the WIHS and Multicenter AIDS Cohort Study (MACS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH); Johns Hopkins Institute for Clinical and Translational Research, or National Center for Advancing Translational Sciences.
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WIHS (Principal Investigators): Bronx WIHS (Kathryn Anastos), U01-AI-035004; Brooklyn WIHS (Howard Minkoff and Deborah Gustafson), U01-AI-031834; Chicago WIHS (Mardge Cohen and Audrey French), U01-AI-034993; Metropolitan Washington WIHS (Seble Kassaye), U01-AI-034994; Connie Wofsy Women’s HIV Study, Northern California (Ruth Greenblatt, Bradley Aouizerat, and Phyllis Tien), U01-AI-034989; WIHS Data Management and Analysis Center (Stephen Gange and Elizabeth Golub), U01-AI-042590; Southern California WIHS (Joel Milam), U01-HD-032632 (WIHS I-WIHS IV). The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). Targeted supplemental funding for specific projects is also provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD), and the NIH Office of Research on Women’s Health. WIHS data collection is also supported by UL1-TR000004 (UCSF CTSA) and UL1-TR000454 (Atlanta CTSA). MACS (Principal Investigators): Johns Hopkins University Bloomberg School of Public Health (Joseph Margolick), U01-AI35042; Northwestern University (Steven Wolinsky), U01-AI35039; University of California, Los Angeles (Roger Detels), U01-AI35040; University of Pittsburgh (Charles Rinaldo), U01-AI35041; the Center for Analysis and Management of MACS, Johns Hopkins University Bloomberg School of Public Health (Lisa Jacobson), UM1-AI35043. The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH). Targeted supplemental funding for specific projects was also provided by the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute on Deafness and Communication Disorders (NIDCD). MACS data collection is also supported by UL1-TR001079 (JHU ICTR) from the National Center for Advancing Translational Sciences (NCATS) a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. The MACS website is located at http://aidscohortstudy.org/.
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This article was funded by Kelso-Chichetto, NIAAA F31 AA024064.
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Kelso-Chichetto, N.E., Okafor, C.N., Cook, R.L. et al. Association Between Depressive Symptom Patterns and Clinical Profiles Among Persons Living with HIV. AIDS Behav 22, 1411–1422 (2018). https://doi.org/10.1007/s10461-017-1822-6
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DOI: https://doi.org/10.1007/s10461-017-1822-6