Abstract
Irregular participation in HIV medical care hinders HIV RNA suppression and impacts health among people living with HIV. Cluster analysis of clinical data from 1,748 patients attending a large academic medical center yielded three HIV service usage patterns, namely: ‘engaged in care’, ‘sporadic care’, and ‘frequent use’. Patients ‘engaged in care’ exhibited most consistent retention (on average, >88 % of each patient’s observation years had ≥2 visits 90 days apart), annualized visit use (2.9 mean visits/year) and viral suppression (>73 % HIV RNA tests <400 c/mL). Patients in ‘sporadic care’ demonstrated lower retention (46–52 %), visit use (1.7 visits/year) and viral suppression (56 % <400 c/mL). Patients with ‘frequent use’ (5.2 visits/year) had more inpatient and emergency visits. Female, out-of-state residence, low attendance during the first observation year and detectable first-observed HIV RNA were early predictors of subsequent service usage. Patients ‘engaged in care’ were more likely to have HIV RNA <400 than those receiving sporadic care. Results confirm earlier findings that under-utilization of services predicts poorer viral suppression and health outcomes and support recommendations for 2–3 visits/year.
Similar content being viewed by others
References
Lewden C, Bouteloup V, De Wit S, Sabin C, Mocroft A, Collaboration of Observational HIV Epidemiological Research Europe (COHERE), et al. All-cause mortality in treated HIV-infected adults with CD4 ≥500/mm3 compared with the general population: evidence from a large European observational cohort collaboration. Int J Epidemiol. 2012;41(2):433–45.
Mayer KH. Introduction: linkage, engagement, and retention in HIV care: essential for optimal individual- and community-level outcomes in the era of highly active antiretroviral therapy. Clin Infect Dis. 2011;52(Suppl 2):S205–7.
Cohen SM, Van Handel MM, Branson BM, Blair JM, Hall HI, Hu X, et al. Vital signs: hIV prevention through care and treatment — United States. Morb Mortal Wkly Rep. 2011;60(47):1618–23.
Doshi RK, Matthews T, Isenberg D, Matosky M, Milberg J, Malitz F, et al., editors. Continuum of HIV care among Ryan White HIV/AIDS Program clients, United States, 2010. Conference on Retroviruses and Opportunistic Infections; 2013; Atlanta, GA.
Gardner EM, McLees MP, Steiner JF, Del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011;52(6):793–800.
Hall HI, Frazier EL, Rhodes P, Holtgrave DR, Furlow-Parmley C, Tang T, et al., editors. Continuum of HIV care: differences in care and treatment by sex and race/ethnicity in the United States. Internatinal AIDS Conference; 2012; Washington, D.C.
Horberg M, Hurley L, Towner W, Gambatese R, Klein D, Antoniskis D, et al., editors. HIV spectrum of engagement cascade in a large integrated care system by gender, age, and methodologies. Conference on Retroviruses and Opportunistic Infections; 2013; Atlanta, GA.
Althoff K, Rebeiro P, Brooks JT, et al. Disparities in the quality of HIV care when using US Department of Health and Human Services indicators. Clin Infect Dis. 2014;58(8):1185–9.
Giordano TP, Gifford AL, White AC Jr, Suarez-Almazor ME, Rabeneck L, Hartman C, et al. Retention in care: a challenge to survival with HIV infection. Clin Infect Dis. 2007;44(11):1493–9.
Mugavero MJ, Lin HY, Willig JH, Westfall AO, Ulett KB, Routman JS, et al. Missed visits and mortality among patients establishing initial outpatient HIV treatment. Clin Infect Dis. 2009;48(2):248–56.
Crawford TN, Sanderson WT, Thornton A. Impact of poor retention in HIV medical care on time to viral load suppression. J Int Assoc Provid AIDS Care. 2014;13(3):242–9.
Hanna DB, Selik RM, Tang T, Gange SJ. Disparities among US states in HIV-related mortality in persons with HIV infection, 2001–2007. Aids. 2012;26(1):95–103.
Crawford TN, Sanderson WT, Thornton A. A comparison study of methods for measuring retention in HIV medical care. AIDS Behav. 2013;17(9):3145–51.
Mugavero MJ, Amico KR, Westfall AO, Crane HM, Zinski A, Willig JA, et al. Early retention in HIV care and viral load suppression: implications for a test and treat approach to HIV prevention. J Acquir Immune Defic Syndr. 2012;59:86–93.
Shepherd BE, Blevins M, Vaz LM, Moon TD, Kipp AM, Jose E, et al. Impact of definitions of loss to follow-up on estimates of retention, disease progression, and mortality: application to an HIV program in Mozambique. Am J Epidemiol. 2013;178(5):819–28.
Yehia BR, Fleishman JA, Metlay JP, Korthuis PT, Agwu AL, Berry SA, et al. Comparing different measures of retention in outpatient HIV care. Aids. 2012;26(9):1131–9.
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents2013 6/23/2013. Available from: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
Human Resources and Services Administration HIV/AIDS Bureau. Performance Measure for Adult/Adolescent Clients: Group 12008 August 5, 2013. Available from: http://hab.hrsa.gov/deliverhivaidscare/habperformmeasures.html.
Mugavero M, Westfall AO, Zinski A, Davila J, Drainoni ML, Gardner LI, et al. Measuring retention in HIV care: the elusive gold standard. J Acquir Immune Defic Syndr. 2012;61(5):574–80.
Madec Y, Boufassa F, Porter K, Prins M, Sabin C, d’Arminio Monforte A, et al. Natural history of HIV-control since seroconversion. Aids. 2013;27(15):2451–60.
Hosmer DW, Lemeshow S. Applied logistic regression. New York City: Wiley; 2000.
Buscher A, Mugavero M, Westfall AO, Keruly J, Moore R, Drainoni ML, et al. The association of clinical follow-up intervals in HIV-infected persons with viral suppression on subsequent viral suppression. AIDS Patient Care STDS. 2013;27(8):459–66.
Adeyemi OM, Livak B, McLoyd P, Smith KY, French AL. Racial/ethnic disparities in engagement in care and viral suppression in a large urban HIV clinic. Clin Infect Dis. 2013;56(10):1512–4.
Moore RD, Keruly JC, Bartlett JG. Improvement in the health of HIV-infected persons in care: reducing disparities. Clin Infect Dis. 2012;55(9):1242–51.
Horberg M, Hurley LB, Silverberg MJ, Klein DB, Quesenberry CP, Mugavero MJ. Missed office visits and risk of mortality among HIV-infected subjects in a large healthcare system in the United States. AIDS Patient Care STDS. 2013;27(8):442–9.
Keller SC, Yehia BR, Eberhart MG, Brady KA. Accuracy of definitions for linkage to care in persons living with HIV. J Acquir Immune Defic Syndr. 2013;63(5):622–30.
Krentz HB, Worthington H, Gill MJ. Adverse health effects for individuals who move between HIV care centers. J Acquir Immune Defic Syndr. 2011;57(1):51–4.
Thompson MA, Mugavero MJ, Amico KR, Cargill VA, Chang LW, Gross R, et al. Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel. Ann Intern Med. 2012;156(11):817–33.
Hall HI, Gray KM, Tang T, Li J, Shouse L, Mermin J. Retention in care of adults and adolescents living with HIV in 13 U.S. areas. J Acquir Immune Defic Syndr. 2012;60(1):77–82.
Losina E, Schackman BR, Sadownik SN, Gebo KA, Walensky RP, Chiosi JJ, et al. Racial and sex disparities in life expectancy losses among HIV-infected persons in the united states: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapy. Clin Infect Dis. 2009;49(10):1570–8.
Higa DH, Marks G, Crepaz N, Liau A, Lyles CM. Interventions to improve retention in HIV primary care: a systematic review of U.S. studies. Current HIV/AIDS Rep. 2012;9(4):313–25.
Acknowledgments
This research was supported by funds from HRSA’s Special Projects of National Significance program (HA15148, H9HA15152), UNC Centers for AIDS Research (P30-AI50410) and the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (1UL1TR001111). This study was conducted with the approval of the University of North Carolina at Chapel Hill Institutional Review. The authors also acknowledge the clinic staff, providers, and patients for their invaluable contributions to this research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or HRSA.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Palma, A., Lounsbury, D.W., Messer, L. et al. Patterns of HIV Service Use and HIV Viral Suppression Among Patients Treated in an Academic Infectious Diseases Clinic in North Carolina. AIDS Behav 19, 694–703 (2015). https://doi.org/10.1007/s10461-014-0907-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10461-014-0907-8