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Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

  • Additive Manufacturing of Biomaterials, Tissues, and Organs
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Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.

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Acknowledgments

This study was supported by NSF grants 1462232 and CAREER 1349716, GAP Award from The University of Iowa, NIH grant 1R21DE024206-01A1, the Center for Biocatalysis and Bioprocessing Graduate Fellowship, and the Lyle and Sharon Bighley Professorship.

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Authors and Affiliations

  1. Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, USA

    Anh-Vu Do, Sean Geary & Aliasger K. Salem

  2. Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa, IA, USA

    Anh-Vu Do, Brian Green & Aliasger K. Salem

  3. Center for Computer-Aided Design, College of Engineering, University of Iowa, Iowa, IA, USA

    Adil Akkouch, Ibrahim Ozbolat & Amer Debabneh

  4. Department of Engineering Science and Mechanics, Penn State University, State College, PA, USA

    Ibrahim Ozbolat

  5. The Huck Institutes of the Life Sciences, Penn State University, State College, PA, USA

    Ibrahim Ozbolat

Authors
  1. Anh-Vu Do
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  2. Adil Akkouch
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  3. Brian Green
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  4. Ibrahim Ozbolat
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  5. Amer Debabneh
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  6. Sean Geary
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  7. Aliasger K. Salem
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Corresponding author

Correspondence to Aliasger K. Salem.

Additional information

Associate Editor Amir Abbas Zadpoor oversaw the review of this article.

Invited Manuscript to a Special Theme Issue of Annals of Biomedical Engineering on the topic of “Additive manufacturing and 3D printing of biomaterials” with a submission deadline of January 15th 2016 and revised submission deadline of April 30th 2016.

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Do, AV., Akkouch, A., Green, B. et al. Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes. Ann Biomed Eng 45, 297–305 (2017). https://doi.org/10.1007/s10439-016-1648-9

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  • DOI: https://doi.org/10.1007/s10439-016-1648-9

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