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Relationship between the microvascular patterns observed by magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial pharyngeal squamous cell carcinoma

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Abstract

Background

Prediction of the invasive depth is the objective of endoscopic observation for digestive cancer. In superficial esophageal cancer, a close relationship between microvascular patterns observed by magnifying endoscopy with narrow-band imaging (M-NBI) and pathological depth of invasion is well known. The ability of M-NBI to predict the invasion depth in superficial pharyngeal squamous cell carcinoma (SPSCC) has been seldom evaluated. This study aimed to clarify the relationship between the microvasculature patterns and pathological depth in SPSCC.

Methods

SPSCC lesions evaluated with M-NBI followed by endoscopic resection were analyzed between April 2010 and March 2017. Endoscopic images were classified as microvasculature tumor types B1, B2, and B3 according to the Japan Esophageal Society classification. The pathological depth of invasion was described as either squamous cell carcinoma in situ (Tis) or invasive subepithelial cancer, and the tumor thickness of all lesions was examined. Data were analyzed using the unpaired t, χ2, or Mann–Whitney U test.

Results

Type B1 and type B2/B3 (35/3) microvessels were found in 180 lesions (82%) and 39 (18%), respectively. Of the flat lesions, 115 (83%) were classified as Tis and 23 (17%) as subepithelial cancer. Positive and negative predictive values of the B1 vessels were 77% and 82%, respectively. Additional analysis showed that the positive predictive value of the B1 vessels for the flat-type lesions was 87%; the negative predictive value for the elevated lesions was 93%.

Conclusions

Microvascular patterns observed by M-NBI are an important factor in predicting the pathological depth of invasion.

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Acknowledgements

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Authors and Affiliations

  1. Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan

    Hironori Sunakawa, Keisuke Hori, Tomohiro Kadota, Kensuke Shinmura, Yusuke Yoda, Hiroaki Ikematsu & Tomonori Yano

  2. Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

    Toshifumi Tomioka & Ryuichi Hayashi

  3. Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan

    Hironori Sunakawa & Tetsuo Akimoto

  4. Department of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Kashiwa, Chiba, Japan

    Tetsuo Akimoto

  5. Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan

    Satoshi Fujii

Authors
  1. Hironori Sunakawa
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  2. Keisuke Hori
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  3. Tomohiro Kadota
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  4. Kensuke Shinmura
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  5. Yusuke Yoda
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  6. Hiroaki Ikematsu
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  7. Toshifumi Tomioka
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  8. Tetsuo Akimoto
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  9. Ryuichi Hayashi
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  10. Satoshi Fujii
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  11. Tomonori Yano
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Corresponding author

Correspondence to Tomonori Yano.

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Ethical statement

All patients were informed of the treatment-related risks and provided written consent before the endoscopic procedures. This study was conducted with approval from the Institutional Review Board of the National Cancer Center Japan (approval number: 2017-434).

Conflict of interest

Sunakawa Hironori, Hori Keisuke, Kadota Tomohiro, Shinmura Kensuke, Yoda Yusuke, Ikematsu Hiroaki, Tomioka Toshifumi, Akimoto Tetsuo, Hayashi Ryuichi, Fuji Satoshi, and Yano Tomonori declare no conflicts of interest.

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Sunakawa, H., Hori, K., Kadota, T. et al. Relationship between the microvascular patterns observed by magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial pharyngeal squamous cell carcinoma. Esophagus 18, 111–117 (2021). https://doi.org/10.1007/s10388-020-00754-5

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  • DOI: https://doi.org/10.1007/s10388-020-00754-5

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