Skip to main content

Advertisement

SpringerLink
Log in

Structure-function relationship between magnetic resonance imaging lesion areas and visual field defects in initial optic neuritis with altitudinal hemianopsia

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To study the spatial association of magnetic resonance imaging (MRI) contrast enhancement (CE) areas with visual field defect (VFD) asymmetry in initial cases of optic neuritis (ON) with altitudinal hemianopsia (AH) with reference to nonarteritic anterior ischemic optic neuropathy (NAION) with AH.

Study design

Multicenter, cross-sectional study.

Methods

The present study comprised 19 ON patients and 20 NAION patients with AH who underwent orbital contrast fat-suppressed MRI. The signal-to-intensity ratio (SIR) was calculated by dividing the maximum CE of the optic nerve by the mean CE of the cerebral white matter in 11 coronal sections at 3-mm intervals from immediately posterior to the eyeball to the optic chiasm. Sections in ON patients with an SIR exceeding the mean plus 2 standard deviations of the SIR at the corresponding section in the NAION group were considered abnormal. The correlation between upper-to-lower CE asymmetry in the maximum SIR section and VFD counterpart was determined.

Results

The ON group had significantly higher maximum SIR than that of the NAION group (1.77 ± 0.88 vs. 1.25 ± 0.32; P < .01). Seven of the 19 patients had sections with abnormally high CE extending posteriorly beyond the orbital apex. Significant spatial correspondence was observed between CE and VFD asymmetry (rs = 0.563; P = .015) in the ON group but not in the NAION group (rs = − 0. 048; P = .850).

Conclusions

ON patients with AH frequently show CE even in the intracerebral optic nerve, maintaining a moderate structure-function correspondence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Toosy AT, Mason DF, Miller DH. Optic neuritis. Lancet Neurol. 2014;13:83–99.

    Article  CAS  PubMed  Google Scholar 

  2. Abel A, McClelland C, Lee MS. Critical review: typical and atypical optic neuritis. Surv Ophthalmol. 2019;64:770–9.

    Article  PubMed  Google Scholar 

  3. Ishikawa H, Kezuka T, Shikishima K, Yamagami A, Hiraoka M, Chuman H, et al. Epidemiologic and clinical characteristics of optic neuritis in Japan. Ophthalmology. 2019;126:1385–98.

    Article  PubMed  Google Scholar 

  4. Chen JJ, Tobin WO, Majed M, Jitprapaikulsan J, Fryer JP, Leavitt JA, et al. Prevalence of myelin oligodendrocyte glycoprotein and aquaporin-4-IgG in patients in the Optic Neuritis Treatment Trial. JAMA Ophthalmol. 2018;136:419–22.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Rizzo JF 3rd, Lessell S. Optic neuritis and ischemic optic neuropathy: overlapping clinical profiles. Arch Ophthalmol. 1991;109:1668–72.

    Article  PubMed  Google Scholar 

  6. Gerling J, Meyer JH, Kommerell G. Visual field defects in optic neuritis and anterior ischemic optic neuropathy: distinctive features. Graefes Arch Clin Exp Ophthalmol. 1998;236:188–92.

    Article  CAS  PubMed  Google Scholar 

  7. Biousse V, Newman NJ. Ischemic optic neuropathies. N Engl J Med. 2015;372:2428–36.

    Article  CAS  PubMed  Google Scholar 

  8. Keltner JL, Johnson CA, Spurr JO, Beck RW. Baseline visual field profile of optic neuritis: the experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group. Arch Ophthalmol. 1993;111:231–4.

    Article  CAS  PubMed  Google Scholar 

  9. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17:162–73.

    Article  PubMed  Google Scholar 

  10. Onodera M, Yama N, Hashimoto M, Shonai T, Aratani K, Takashima H, et al. The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis. Eur Radiol. 2016;26:2640–5.

    Article  PubMed  Google Scholar 

  11. Youl BD, Turano G, Miller DH, Towell AD, MacManus DG, Moore SG, et al. The pathophysiology of acute optic neuritis: an association of gadolinium leakage with clinical and electrophysiological deficits. Brain. 1991;114:2437–50.

    Article  PubMed  Google Scholar 

  12. Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res. 2007;26:688–710.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ueda K, Kanamori A, Akashi A, Kawaka Y, Yamada Y, Nakamura M. Difference in correspondence between visual field defect and inner macular layer thickness measured using three types of spectral-domain OCT instruments. Jpn J Ophthalmol. 2015;59:55–64.

    Article  PubMed  Google Scholar 

  14. Webb N. The visual system. In: Cocchiarella L, Andersson GBJ, editors. Guides to the evaluation of Permanent Impairment. 5th ed. American Medical Association; 2001. pp. 286–300.

  15. Lee S, Kim SJ, Yu YS, Kim YH, Paek SH, Kim DG, et al. Prognostic factors for visual recovery after transsphenoidal pituitary adenectomy. Br J Neurosurg. 2013;27:425–9.

    Article  PubMed  Google Scholar 

  16. Horton JC, Greenwood MM, Hubel DH. Non-retinotopic arrangement of fibres in cat optic nerve. Nature. 1979;282:720–2.

    Article  CAS  PubMed  Google Scholar 

  17. Naito J. Retinogeniculate projection fibers in the monkey optic chiasm: a demonstration of the fiber arrangement by means of wheat germ agglutinin conjugated to horseradish peroxidase. J Comp Neurol. 1994;346:559–71.

    Article  CAS  PubMed  Google Scholar 

  18. Horton JC. Wilbrand’s knee: to be or not to be a knee? J Neuroophthalmol. 2020;40(Suppl 1):7–S14.

    Article  Google Scholar 

  19. Hood DC. Does retinal ganglion cell loss precede visual field loss in glaucoma? J Glaucoma. 2019;28:945–51.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Green AJ, Cree BAC. Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica following optic neuritis. J Neurol Neurosurg Psychiatry. 2009;80:1002–5.

    Article  CAS  PubMed  Google Scholar 

  21. Nakajima H, Hosokawa T, Sugino M, Kimura F, Sugasawa J, Hanafusa T, et al. Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis. BMC Neurol. 2010;10:45.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Liu B, Yu Y, Liu W, Deng T, Xiang D. Risk factors for non-arteritic anterior ischemic optic neuropathy: a large scale meta-analysis. Front Med (Lausanne). 2021;8:618353.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported in part by a grant-in-aid (no. 21K09675) from the Japan Society for the Promotion of Science (to M.N.).

Author information

Authors and Affiliations

  1. Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Hirotaka Ochi, Takuji Kurimoto & Makoto Nakamura

  2. Inouye Eye Hospital, Tokyo, Japan

    Akiko Yamagami

  3. Kawasaki Medical School, Department of Ophthalmology, Kurashiki, Japan

    Katsutoshi Goto & Atsushi Miki

  4. Department of Ophthalmology, School of Medicine, Kitasato University, Sagamihara,, Japan

    Manami Kawai

  5. Department of Orthoptics and Visual Science, Kitasato University School of Allied Health Sciences, Sagamihara, Japan

    Hitoshi Ishikawa

  6. Kobe City Eye Hospital, Kobe, Japan

    Hirotaka Ochi & Mitsuhiro Matsuzaki

  7. Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan

    Hirotaka Ochi & Mitsuhiro Matsuzaki

  8. Department of Ophthalmology, Hyogo Medical University, Nishinomiya, Japan

    Miho Kondo, Yoshihito Mochizuki & Akiko Kimura

  9. Miyake Eye Hospital, Nagoya, Japan

    Tomoyuki Maekubo

  10. Faculty of Medicine, Department of Ophthalmology, University of Miyazaki, Miyazaki, Japan

    Hideki Chuman

  11. Graduate School of Medical and Dental Sciences, Division of Ophthalmology and Visual Science, Niigata University, Niigata, Japan

    Satoshi Ueki

Authors
  1. Hirotaka Ochi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takuji Kurimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Akiko Yamagami
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Katsutoshi Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Atsushi Miki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Manami Kawai
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hitoshi Ishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mitsuhiro Matsuzaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Miho Kondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yoshihito Mochizuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Akiko Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Tomoyuki Maekubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Hideki Chuman
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Satoshi Ueki
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Makoto Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Makoto Nakamura.

Ethics declarations

Conflict of interest

H. Ochi, None; T. Kurimoto, None; A. Yamagami, None; K. Goto, None; A. Miki, None; M. Kawai, None; H. Ishikawa, None; M. Matsuzaki, None; M. Kondo, None; Y. Mochizuki, None; A. Kimura, None; T. Maekubo, None; H. Chuman, None; S. Ueki, None; M. Nakamura, None.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Corresponding Author: Makoto Nakamura.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ochi, H., Kurimoto, T., Yamagami, A. et al. Structure-function relationship between magnetic resonance imaging lesion areas and visual field defects in initial optic neuritis with altitudinal hemianopsia. Jpn J Ophthalmol 67, 618–627 (2023). https://doi.org/10.1007/s10384-023-01008-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-023-01008-4

Keywords

Search

Navigation